Evidence map›Paper›PMID 30925677›Full record

ArticleInternational journal of molecular sciences2019

Identification, Characterization, and Regulatory Mechanisms of a Novel EGR1 Splicing Isoform.

Vincenza Aliperti, Giulia Sgueglia, Francesco Aniello, Emilia Vitale, Laura Fucci, Aldo Donizetti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vincenza AlipertiDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy. vincenza.aliperti@unina.it.
Giulia SguegliaDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy. giulia.sgueglia@live.com.
Francesco AnielloDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy. faniello@unina.it.
Emilia VitaleNeurOmics Laboratory, Institute of Protein Biochemistry (IBP), CNR, 80131 Naples, Italy. e.vitale@ibp.cnr.it.
Laura FucciDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy. fucci@unina.it.
Aldo DonizettiDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy. aldo.donizetti@unina.it.
University of Naples Federico II · ITInstitute of Protein Biochemistry · IT

Funding

Regione Campania CUP B25C13000240007
6 · The paper itself

Abstract

EGR1 is a transcription factor expressed in many cell types that regulates genes involved in different biological processes including growth, proliferation, and apoptosis. Dysregulation of EGR1 expression has been associated with many pathological conditions such as tumors and brain diseases. Known molecular mechanisms underlying the control of EGR1 function include regulation of transcription, mRNA and protein stability, and post-translational modifications. Here we describe the identification of a splicing isoform for the human

Indexed as

Alternative SplicingCell LineEarly Growth Response Protein 1Gene Expression RegulationHEK293 CellsHumansProtein IsoformsRNA, MessengerEarly Growth Response Protein 1EGR1 protein, humanProtein IsoformsRNA, Messengeralternative splicingEGR1exitrongene expression regulationimmediate early genes

Identifiers

PMID30925677
PMCPMC6479754
OpenAlexW2924604839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.