Evidence map›Paper›PMID 30925582›Full record

ArticlePloS one2019

Barriers to HIV pre-exposure prophylaxis among African, Caribbean and Black men in Toronto, Canada.

Alice Zhabokritsky, LaRon E Nelson, Wangari Tharao, Winston Husbands, Ting Sa, Nanhua Zhang, Jamie Thomas-Pavanel, Shamara Baidoobonso, Rupert Kaul

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. HIV testing among heterosexual Black men in Toronto: What are the determinants?Canadian journal of public health = Revue canadienne de sante publique · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex With Men in Ottawa: A Real World View With Benefits Beyond HIV Risk Reduction.International journal of sexual health : official journal of the World Association for Sexual Health · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Alice ZhabokritskyUniversity of Toronto, Department of Medicine, Toronto, Canada.ORCID 0000-0002-2306-0677
LaRon E NelsonSt. Michael's Hospital, Li Ka Shing Knowledge Institute, Center for Urban Health Solutions, Toronto, Canada.
Wangari TharaoWomen's Health in Women's Hands, Toronto, Canada.
Winston HusbandsOntario HIV Treatment Network, Toronto, Canada.
Ting SaCincinnati Children's Hospital Medical Center, Department of Biostatistics and Epidemiology, Cincinnati, OH, United States of America.
Nanhua ZhangCincinnati Children's Hospital Medical Center, Department of Biostatistics and Epidemiology, Cincinnati, OH, United States of America.
Jamie Thomas-PavanelWomen's College Research Institute, Women's College Hospital, Toronto, Canada.
Shamara BaidoobonsoChief Public Health Office, Charlottetown, Prince Edward Island, Canada.
Rupert KaulUniversity of Toronto, Departments of Medicine and Immunology, Toronto, Canada.
Cincinnati Children's Hospital Medical Center · USUniversity of Toronto · CAHealth PEI · CAOntario HIV Treatment Network · CASt. Michael's Hospital · CAWomen's College Hospital · CAWomen's Health In Women's Hands · CA

Funding

Minority Populations Prevention Researcher TrainingR25HD045810 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEILANDS, TORSTEN BRIAN · 2003 to 2018
$4.3M
CIHR HET-85518CIHR TMI-138656NICHD NIH HHS R25 HD045810
6 · The paper itself

Abstract

introductionSingle-tablet combination emtricitabine/tenofovir is highly effective as HIV pre-exposure prophylaxis (PrEP). Scale-up efforts have targeted men who have sex with men (MSM), but patterns of racial disparities in PrEP use have begun to emerge. African, Caribbean and Black (ACB) communities in Canada and USA are also disproportionately affected by HIV, and there is lack of guidance regarding PrEP implementation in this priority population.

methodsACB men from Toronto, Canada were recruited in community settings by peers. Participants completed a detailed socio-behavioural questionnaire. Biological samples were collected and tested for sexually transmitted infections. Willingness to accept PrEP was assessed in relation to actual and self-perceived risk of acquiring HIV, as well as demographic and behavioural variables.

results424 ACB men were included in the analysis. ACB MSM were more likely to accept PrEP than ACB men only reporting sex with women (MSW; 50.0% vs. 23.6%). The most common reasons for PrEP non-acceptance were concerns regarding side-effects and low self-perceived risk. PrEP acceptance was lowest among younger men (12.5%) and those born in Canada (15.2%). Men with a high self-perceived HIV risk were more likely to accept PrEP (41.3% vs. 22.7% of men with a low self-perceived risk), but only 25.4% of men who were defined as being at high-risk, self-identified themselves as such.

conclusionsMost ACB MSW were unlikely to accept PrEP, largely due to low self-perceived HIV risk, but PrEP acceptance among ACB MSM was similar to other contemporaneous Toronto MSM communities. PrEP acceptance was particularly low among younger ACB men and those born in Canada. Tailored strategies will be needed to effectively implement PrEP in Toronto ACB communities.

Indexed as

AdolescentAdultAge FactorsAnti-HIV AgentsBlack or African AmericanCanadaEmtricitabineHealth Knowledge, Attitudes, PracticeHispanic or LatinoHIV InfectionsHomosexuality, MaleHumansLogistic ModelsMaleMiddle AgedPre-Exposure ProphylaxisAnti-HIV AgentsEmtricitabineTenofovir

Identifiers

PMID30925582
PMCPMC6440797
OpenAlexW2925576807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.