Evidence map›Paper›PMID 30925441›Full record

ArticleEnvironmental research2019

lifetime exposure to traffic-related air pollution and symptoms of depression and anxiety at age 12 years.

Kimberly Yolton, Jane C Khoury, Jeffrey Burkle, Grace LeMasters, Kim Cecil, Patrick Ryan

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021
    Pooled it
  3. Revisiting 'environmental effects': Directions for multidisciplinary investigations of air quality and psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  4. Article
  5. Article
  6. Urban mental health: a position paper of the European psychiatric association.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Air Pollution's Hidden Toll: Links Between Ozone, Particulate Matter, and Adolescent Depression.International journal of environmental research and public health · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. PMProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Association between prenatal and childhood PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kimberly YoltonDivision of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, United States. Electronic address: kimbely.yolton@cchmc.org.
Jane C KhouryDivision of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, United States.
Jeffrey BurkleDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, United States.
Grace LeMastersDepartment of Environmental Health, University of Cincinnati College of Medicine, United States.
Kim CecilDepartment of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, United States.
Patrick RyanDivision of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, United States.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · NIEHS · UNIVERSITY OF CINCINNATI · PI Kelly J Brunst · 2001 to 2026
$11.1M
Diesel, Allergens and Gene Interaction and Child AtopyR01ES011170 · NIEHS · UNIVERSITY OF CINCINNATI · PI LEMASTERS, GRACE · 2001 to 2009
$10.4M
Neurobehavioral and Neuroimaging Effects of Traffic Exposure in ChildrenR01ES019890 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI RYAN, PATRICK H · 2012 to 2016
$3.1M
Developmental Effects of Manganese Exposure in Rural Adolescents: The CARES Cohort Comes of AgeR01ES026446 · NIEHS · UNIVERSITY OF KENTUCKY · PI CECIL, KIM M, HAYNES, ERIN N · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES011170NIEHS NIH HHS R01 ES019890NIEHS NIH HHS R01 ES026446NIEHS NIH HHS T32 ES010957
6 · The paper itself

Abstract

backgroundWhile air pollution has been associated with depression and anxiety in adults, its impact on childhood mental health is understudied.

objectiveWe examined lifetime exposure to traffic-related air pollution (TRAP) and symptoms of depression and anxiety at age 12 years in the Cincinnati Childhood Allergy and Air Pollution Study cohort.

methodsWe estimated exposure to elemental carbon attributable to traffic (ECAT), a surrogate of diesel exhaust, at birth, age 12 years, and average exposure throughout childhood, using a validated land use regression model. We assessed depression and anxiety at age 12 years by parent report with the Behavior Assessment System for Children-2, and by child report with the Child Depression Inventory-2 (CDI-2) and the Spence Children's Anxiety Scale (SCAS). Associations between TRAP at birth, age 12 years, and childhood average and mental health outcomes were estimated using linear regression models adjusting for covariates including parent depression, secondhand smoke exposure, race, household income, and others.

resultsExposure to ECAT was not significantly associated with parent-reported depression or anxiety. However, exposure to ECAT at birth was associated with increased child-reported depression and anxiety. Each 0.25 µg/m

conclusionsTRAP exposure during early life and across childhood was significantly associated with self-reported depression and anxiety symptoms in children. The negative impact of air pollution on mental health previously reported among adults may also be present during childhood.

Indexed as

Air PollutantsAdultAir PollutionAnxietyChildDepressionEnvironmental ExposureHumansVehicle EmissionsAir PollutantsVehicle EmissionsAir pollutionAnxietyChild mental healthDepressionExposure

Identifiers

PMID30925441
PMCPMC7388180
OpenAlexW2919528338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.