Evidence map›Paper›PMID 30925405›Full record

ArticleChemosphere2019

Sulfonation and glucuronidation of hydroxylated bromodiphenyl ethers in human liver.

Katherine V Cisneros, Vinayak Agarwal, Margaret O James

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemosphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Katherine V CisnerosDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610-0485, USA.
Vinayak AgarwalSchool of Chemistry and Biochemistry, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Margaret O JamesDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610-0485, USA. Electronic address: mojames@ufl.edu.
University of Florida · USGeorgia Institute of Technology · US

Funding

Understanding natural production of polybrominated toxins and pollutantsR00ES026620 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI AGARWAL, VINAYAK · 2017 to 2019
$747k
NIEHS NIH HHS R00 ES026620
6 · The paper itself

Abstract

Hydroxylated bromodiphenyl ethers (OH-BDEs) can arise from monooxygenation of anthropogenic BDEs or through natural biosynthetic processes in marine organisms, and several OH-BDEs have been shown to be toxic. OH-BDEs are expected to form sulfate and glucuronide conjugates that are readily excreted, however there is little information on these pathways. We examined the human hepatic glucuronidation and sulfonation of 6-OH-BDE47, 2-OH-BDE68, 4-OH-BDE68 and 2-OH-6'methoxy-BDE68. Human liver microsomes and cytosol were from de-identified female and male donors aged 31 to 75 under an exempt protocol. Recombinant human SULT1A1, 1B1, 1E1 and 2A1 enzymes were prepared from bacterial expression systems. Sulfonation and glucuronidation of each OH-BDE were studied using radiolabeled co-substrates, 3'phosphoadenosine-5'phospho-

Indexed as

AdultAgedCytosolEthersFemaleGlucuronidesHumansHydroxylationLiverMaleMicrosomes, LiverMiddle AgedPolybrominated BiphenylsSulfates6-OH-BDE-47EthersGlucuronidesPolybrominated BiphenylsSulfatesGlucuronidationHydroxy-bromodiphenyl ethersPhase II metabolismSulfonation

Identifiers

PMID30925405
PMCPMC6516465
OpenAlexW2925170296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.