ArticleBiomaterials2019
Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Thin-Film Reference Electrodes for Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2025Article
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation.Neuroscience bulletin · 2025Article
- Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring.Micromachines · 2024Article
- Article
- Through-polymer, via technology-enabled, flexible, lightweight, and integrated devices for implantable neural probes.Microsystems & nanoengineering · 2024Article
- Intracortical brain-computer interfaces in primates: a review and outlook.Biomedical engineering letters · 2023Review
- Full-field, conformal epiretinal electrode array using hydrogel and polymer hybrid technology.Scientific reports · 2023Article
- Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition.Advanced healthcare materials · 2022Article
- Recent Advances in Cochlear Implant Electrode Array Design Parameters.Micromachines · 2022Review
- In Vivo Sensing of pH in Tomato Plants Using a Low-Cost and Open-Source Device for Precision Agriculture.Biosensors · 2022Article
- Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser.Microsystems & nanoengineering · 2022Article
- Carbon fiber electrodes for intracellular recording and stimulation.Journal of neural engineering · 2021Article
- Article
- Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording.Journal of visualized experiments : JoVE · 2021Article
- Compositional and morphological properties of platinum-iridium electrodeposited on carbon fiber microelectrodes.Journal of neural engineering · 2021Article
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
- Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine.Bioelectronic medicine · 2021Article
- Flexible, high-resolution thin-film electrodes for human and animal neural research.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Reliable single unit neuron recordings from chronically implanted microelectrode arrays (MEAs) are essential tools in the field of neural engineering. However, following implantation, MEAs undergo a foreign body response that functionally isolates them from the brain and reduces the useful longevity of the array. We tested a novel electrodeposited platinum-iridium coating (EPIC) on penetrating recording MEAs to determine if it improved recording performance. We chronically implanted the arrays in rats and used electrophysiological and histological measurements to compare quantitatively the single unit recording performance of coated vs. uncoated electrodes over a 12-week period. The coated electrodes had substantially lower impedance at 1 kHz and reduced noise, increased signal-to-noise ratio, and increased number of discernible units per electrode as compared to uncoated electrodes. Post-mortem immunohistochemistry showed no significant differences in the immune response between coated and uncoated electrodes. Overall, the EPIC arrays provided superior recording performance than uncoated arrays, likely due to lower electrode impedance and reduced noise.
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Registered trials
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