ArticleNeuroImage. Clinical2019
Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.Neuroscience and biobehavioral reviews · 2022Pooled it
- Decreased amygdala volume in adults after premature birth.Scientific reports · 2021Trial
- Relationships between cerebral blood flow and cognition in young adults born very preterm and at term.Scientific reports · 2026Article
- Alterations in Corpus Callosum Subregion Microstructure Associated With Visual Dysfunction in Individuals With Cerebral Visual Impairment.Behavioural neurology · 2026Observational
- Visuospatial outcomes of a prospective national cohort of young adults with very low birthweight.Pediatric research · 2025Article
- Early life factors and structural brain network in children with overweight/obesity: The ActiveBrains project.Pediatric research · 2024Article
- Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight.Scientific reports · 2024Article
- Altered gray-to-white matter tissue contrast in preterm-born adults.CNS neuroscience & therapeutics · 2023Article
- Indirect evidence for altered dopaminergic neurotransmission in very premature-born adults.Human brain mapping · 2023Article
- Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age.Scientific reports · 2023Article
- Article
- Sleep across the first year of life is prospectively associated with brain volume in 12-months old infants.Neurobiology of sleep and circadian rhythms · 2023Article
- [Birth conditions and attention deficit/hyperactivity disorders (ADHD) in adults in the Pelotas (Brazil) birth cohorts of 1982 and 1993].Cadernos de saude publica · 2023Article
- Aberrant allometric scaling of cortical folding in preterm-born adults.Brain communications · 2023Article
- Predict initial subthalamic nucleus stimulation outcome in Parkinson's disease with brain morphology.CNS neuroscience & therapeutics · 2022Article
- Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach.Journal of personalized medicine · 2021Article
- Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A "WHAT-IF" Simulation Study.Pharmaceutics · 2021Article
- Within amygdala: Basolateral parts are selectively impaired in premature-born adults.NeuroImage. Clinical · 2021Article
- Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood.Human brain mapping · 2020Article
- Brain morphological changes in hypokinetic dysarthria of Parkinson's disease and use of machine learning to predict severity.CNS neuroscience & therapeutics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the long-term effects of being born very-low-birth-weight (VLBW, <1500 g) on adult cerebral structural development using a multi-method neuroimaging approach. The New Zealand VLBW study cohort comprised 413 individuals born VLBW in 1986. Of the 338 who survived to discharge, 229 were assessed at age 27-29 years. Of these, 150 had a 3 T MRI scan alongside 50 healthy term-born controls. The VLBW group included 53/57 participants born <28 weeks gestation. MRI analyses included: a) structural MRI to assess grey matter (GM) volume and cortical thickness; b) arterial spin labelling (ASL) to quantify GM perfusion; and c) diffusion tensor imaging (DTI) to measure white matter (WM) integrity. Compared to controls, VLBW adults had smaller GM volumes within frontal, temporal, parietal and occipital cortices, bilateral cingulate gyri and left caudate, as well as greater GM volumes in frontal, temporal and occipital areas. Thinner cortex was observed within frontal, temporal and parietal cortices. VLBW adults also had less GM perfusion within limited temporal areas, bilateral hippocampi and thalami. Finally, lower fractional anisotropy (FA) and axial diffusivity (AD) within principal WM tracts was observed in VLBW subjects. Within the VLBW group, birthweight was positively correlated with GM volume and perfusion in cortical and subcortical regions, as well as FA and AD across numerous principal WM tracts. Between group differences within temporal cortices were evident across all imaging modalities, suggesting that the temporal lobe may be particularly susceptible to disruption in development following preterm birth. Overall, findings reveal enduring and pervasive effects of preterm birth on brain structural development, with individuals born at lower birthweights having greater long-term neuropathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.