ArticleAmerican journal of respiratory and critical care medicine2019
A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Airway Response to Dual Bronchodilation and Its Association with Inflammatory Markers in Treatment-Naïve Chronic Obstructive Pulmonary Disease: A Quantitative Computed Tomography Study.Life (Basel, Switzerland) · 2026Article
- Indices of Childhood Socioeconomic Status and Dysanapsis among Older Adults: The Multi-Ethnic Study of Atherosclerosis Lung Study.Annals of the American Thoracic Society · 2024Article
- Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.EClinicalMedicine · 2024Article
- Lung Structure and Risk of Sleep Apnea in SPIROMICS.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Impact of COPD pulmonary structural remodeling on the prognosis of patients with advanced lung squamous cell carcinoma.Heliyon · 2023Article
- Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023Review
- Microcomputed tomography visualization and quantitation of the pulmonary arterial microvascular tree in mouse models of chronic lung disease.Pulmonary circulation · 2023Article
- Contribution of adaptive immunity to human COPD and experimental models of emphysema.Physiological reviews · 2023Review
- Quantitative assessment of airway wall thickness in COPD patients with interstitial lung abnormalities.Frontiers in medicine · 2023Article
- Review
- A polygenic risk score and age of diagnosis of COPD.The European respiratory journal · 2022Article
- Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.American journal of human genetics · 2022Article
- Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder.The Lancet. Respiratory medicine · 2022Review
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Article
- Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop.Circulation. Cardiovascular imaging · 2021Article
- Host, Gender, and Early-Life Factors as Risks for Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2020Review
- Update in Chronic Obstructive Pulmonary Disease 2019.American journal of respiratory and critical care medicine · 2020Review
- Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.The Lancet. Respiratory medicine · 2020Article
- Why is Disease Penetration So Variable? Role of Genetic Modifiers of Lung Function in Alpha-1 Antitrypsin Deficiency.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2020Review
Corrections and comments
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Authors and funding
25 authors at 17 institutions in 1 country.
Elizabeth C OelsnerDepartment of Medicine, Columbia University College of Physicians & Surgeons, New York, New York.
Victor E OrtegaDivision of Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Benjamin M SmithDepartment of Medicine, Columbia University College of Physicians & Surgeons, New York, New York.
Jennifer N NguyenCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Ani W ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Eric A HoffmanDepartment of Radiology.
Xiuqing GuoLA Biomed.
Kent D TaylorLA Biomed.
Prescott G WoodruffDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California.
David J CouperDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Robert PaineDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Meilan K HanDivision of Pulmonary and Critical Care Medicine, Michigan Medicine, Ann Arbor, Michigan.
Christopher CooperDepartment of Medicine, and.
Mark T DransfieldDivision of Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Gerard CrinerDepartment of Thoracic Medicine, Temple University, Philadelphia, Pennsylvania.
Jerry A KrishnanDivision of Pulmonary and Critical Care, University of Illinois, Chicago, Illinois.
Russell BowlerDivision of Pulmonary and Critical Care, National Jewish, Denver, Colorado; and.
Eugene R BleeckerDepartment of Medicine, University of Arizona, Tucson, Arizona.
Stephen PetersDivision of Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Deborah A MeyersDepartment of Medicine, University of Arizona, Tucson, Arizona.
Jerome I RotterLA Biomed.
R Graham BarrDepartment of Medicine, Columbia University College of Physicians & Surgeons, New York, New York.
Columbia University · USThe Lundquist Institute · USUniversity of Virginia · USUniversity of Arizona · USWake Forest University · USCornell University · USJohns Hopkins University · USMichigan Medicine · USNational Jewish Health · USTemple University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MSOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MChronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K08 HL118128NHLBI NIH HHS K23 HL130627NHLBI NIH HHS K24 HL137013NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL112986NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R01 HL131565NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES006694NIH HHS S10 OD018526
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genetic Predisposition to DiseaseAgedFemaleHumansLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRisk AssessmentTomography, X-Ray ComputedUnited Statesairway remodelingemphysemaspirometry
Identifiers
What OpenQuestion holds
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Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.