ArticleJournal of anatomy2019
Ageing of the somatosensory system at the periphery: age-related changes in cutaneous mechanoreceptors.
Article in Journal of anatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions.Frontiers in neuroscience · 2022Pooled it
- Acute Effects of a Whole Body Vibration Session on the Vibration Perception Threshold in Patients with Type 2 Diabetes Mellitus.International journal of environmental research and public health · 2020Trial
- Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Layer-specific neuroanatomical architecture of the quadratus lumborum: a quantitative study using 3D micro-CT and immunofluorescence staining.Surgical and radiologic anatomy : SRA · 2026Article
- Musculoskeletal degeneration and cardiovascular aging: a narrative review of shared mechanobiological pathways.Molecular biology reports · 2026Review
- Investigating mechanoreceptor variability and morphometric proxies in Rhesus Macaques: Implications for primate precision touch studies.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Choline acetyltransferase as a marker for Merkel cells in mucosal and skin tissues.Journal of oral biosciences · 2026Article
- Age-related changes in hand function - it's not just about muscle strength.Frontiers in human neuroscience · 2026Review
- The use of acoustic myography to assess changes in muscle control with ageing in healthy subjects ranging 20 to 79 years.Journal of muscle research and cell motility · 2025Article
- The effect of over-the-counter analgesics on changes to the sensory sensitivity of patients treated with transcutaneous electrical nerve stimulation.Scientific reports · 2025Observational
- Paying attention to proprioception: age affects ankle proprioception and the attentional demand of proprioceptive processing in sedentary adults.GeroScience · 2025Article
- Sexual Mechanosensitivity: Age-Related Changes in the Innervation of the Human Prepuce.Journal of clinical medicine · 2025Article
- Ultrasonographic Identification of Pacinian Corpuscles in the Hand: A Pilot Study of Technique and Reliability.Muscle & nerve · 2025Article
- The role of skin hydration, skin deformability, and age in tactile friction and perception of materials.Scientific reports · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Morphometric characteristics of tibial nerve and their relationship with age.Brain communications · 2025Article
- Periarticular Proprioception: Analyzing the Three-Dimensional Structure of Corpuscular Mechanosensors in the Dorsal Part of the Scapholunate Ligament.Cells, tissues, organs · 2025Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.Brain : a journal of neurology · 2024Article
- Age related changes in skin sensitivity assessed with smartphone vibration testing.Scientific reports · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse the age-dependent changes in Meissner's and Pacinian corpuscles as well as in Merkel cell-neurite complexes. Moreover, variations in the neurotrophic TrkB-BDNF system and the mechanoprotein Piezo2 (involved in maintenance of cutaneous mechanoreceptors and light touch, respectively) were evaluated. The number of Meissner's corpuscles and Merkel cells decreased progressively with ageing. Meissner's corpuscles were smaller, rounded in morphology and located deeper in the dermis, and signs of corpuscular denervation were found in the oldest subjects. Pacinian corpuscles generally showed no relevant age-related alterations. Reduced expression of Piezo2 in the axon of Meissner's corpuscles and in Merkel cells was observed in old subjects, as well was a decline in the BDNF-TrkB neurotrophic system. This study demonstrates that cutaneous Meissner's corpuscles and Merkel cell-neurite complexes (and less evidently Pacinian corpuscles) undergo morphological and size changes during the ageing process, as well as a reduction in terms of density. Furthermore, the mechanoprotein Piezo2 and the neurotrophic TrkB-BDNF system are reduced in aged corpuscles. Taken together, these alterations might explain part of the impairment of the somatosensory system associated with ageing.
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