Why results from Bayesian statistical analyses of clinical trials with a strong prior and small sample sizes may be misleading The case of the NICHD Neonatal Research Network Late Hypothermia Trial.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

4 citing papers in PubMed.

1. Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025
   Review
2. Variations in care of neonates during therapeutic hypothermia: call for care practice bundle implementation.Pediatric research · 2023
   Article
3. Emerging therapies and management for neonatal encephalopathy-controversies and current approaches.Journal of perinatology : official journal of the California Perinatal Association · 2021
   Review
4. Time to start hypothermia after perinatal asphyxia: does it matter?BMJ paediatrics open · 2019
   Article

Corrections and comments

• Comment on
  Response to a different view concerning the NICHD neonatal research network late hypothermia trial.2019

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as