Evidence map›Paper›PMID 30924523›Full record

ArticleBritish journal of pharmacology2019

VU0810464, a non-urea G protein-gated inwardly rectifying K

Baovi N Vo, Kristopher K Abney, Allison Anderson, Ezequiel Marron Fernandez de Velasco, Michael A Benneyworth, John Scott Daniels, Ryan D Morrison, Corey R Hopkins, Charles David Weaver, Kevin Wickman

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022
    Review
  5. AsKC11, a Kunitz Peptide fromMarine drugs · 2022
    Article
  6. Article
  7. Review
  8. Advances in Targeting GIRK Channels in Disease.Trends in pharmacological sciences · 2021
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Baovi N VoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.
Kristopher K AbneySchool of Graduate Studies and Research, Meharry Medical College, Nashville, TN.
Allison AndersonDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.
Michael A BenneyworthDepartment of Neuroscience, University of Minnesota, Minneapolis, MN.
John Scott DanielsResearch and Development, Precera Bioscience, Inc., Franklin, TN.
Ryan D MorrisonResearch and Development, Precera Bioscience, Inc., Franklin, TN.
Corey R HopkinsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE.
Charles David WeaverDepartments of Pharmacology and Chemistry, Vanderbilt University, Nashville, TN.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-5179-9540
University of Minnesota · USBioScience Laboratories (United States) · USMeharry Medical College · USNebraska Medical Center · USVanderbilt University · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Stephania T. Miller-Hughes · 2017 to 2026
$48.2M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Relevance and plasticity of inhibitory metabotropic signaling in reward circuitsR01DA034696 · NIDA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2013 to 2022
$3.4M
The role of RGS proteins in the parasympathetic control of heart rateR01HL105550 · NHLBI · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A., WICKMAN, KEVIN D · 2011 to 2018
$3.2M
Development of an In Vivo, Brain-penetrant GIRK1/2 Potassium Channel ActivatorR01MH107399 · NIMH · VANDERBILT UNIVERSITY · PI HOPKINS, COREY R., WEAVER, C DAVID · 2015 to 2017
$1.6M
Fluorescent and Luminescent Kinetic Imaging Plate ReaderS10OD021734 · OD · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2016 to 2016
$671k
Targeting the parasympathetic regulation of the heart to treat arrhythmiasF31HL139090 · NHLBI · UNIVERSITY OF MINNESOTA · PI ANDERSON, ALLISON DIANE · 2017 to 2019
$120k
NHLBI NIH HHS F31 HL139090NHLBI NIH HHS R01 HL105550NIDA NIH HHS R01 DA034696NIGMS NIH HHS R25 GM059994NIH HHS S10 OD021734NIMHD NIH HHS U54 MD007586NIMH NIH HHS R01 MH107399
6 · The paper itself

Abstract

background and purposeG protein-gated inwardly rectifying K EXPERIMENTAL APPROACH: We used whole-cell electrophysiology to measure the efficacy and potency of VU0810464 in neurons and the selectivity of VU0810464 for neuronal and cardiac K KEY

resultsVU0810464 and ML297 exhibited comparable efficacy and potency as neuronal K CONCLUSION AND IMPLICATIONS: VU0810464 represents a new class of K

Indexed as

AnimalsAnxietyBehavior, AnimalBrainCells, CulturedFemaleFeverG Protein-Coupled Inwardly-Rectifying Potassium ChannelsMaleMice, Inbred C57BLMice, TransgenicNeuronsSinoatrial NodeStress, PsychologicalG Protein-Coupled Inwardly-Rectifying Potassium Channels

Identifiers

PMID30924523
PMCPMC6555862
OpenAlexW2932997597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.