ArticleNeurosurgery2020
Histotripsy Clot Liquefaction in a Porcine Intracerebral Hemorrhage Model.
Article in Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Pooled it
- Ultrasound-Mediated Thrombolysis: From Mechanistic Insights to Advanced Nanoplatforms and Clinical Translation.Advanced healthcare materials · 2026Review
- Numerical Validation of mSOUND Using Fully Heterogeneous Skull Models.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2026Article
- Neuronavigation-Guided Transcranial Histotripsy (NaviTH) System.Ultrasound in medicine & biology · 2024Article
- Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024Review
- Characterization of Blood-Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains.Ultrasound in medicine & biology · 2024Article
- Histotripsy: an innovative approach for minimally invasive tumour and disease treatment.Annals of medicine and surgery (2012) · 2024Review
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications.Stroke (Hoboken, N.J.) · 2024Article
- Histotripsy Treatment of Murine Brain and Glioma: Temporal Profile of Magnetic Resonance Imaging and Histological Characteristics Post-treatment.Ultrasound in medicine & biology · 2023Article
- A Multimodal Phantom for Visualization and Assessment of Histotripsy Treatments on Ultrasound and X-Ray Imaging.Ultrasound in medicine & biology · 2023Article
- Research progress and clinical evaluation of histotripsy: a narrative review.Annals of translational medicine · 2023Review
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Endoscopic Coregistered Ultrasound Imaging and Precision Histotripsy: InitialBME frontiers · 2022Article
- Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders.Frontiers in neurology · 2022Review
- Minimally Invasive Surgery for Spontaneous Intracerebral Hematoma. Real-Life Implementation Model and Economic Estimation.Frontiers in neurology · 2022Article
- Focused ultrasound: growth potential and future directions in neurosurgery.Journal of neuro-oncology · 2022Review
- Assessing the Evolution of Intracranial Hematomas by using Animal Models: A Review of the Progress and the Challenges.Metabolic brain disease · 2021Review
- 3-D Transcranial Microbubble Cavitation Localization by Four Sensors.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Applications of focused ultrasound in the brain: from thermoablation to drug delivery.Nature reviews. Neurology · 2021Review
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9 authors.
Funding
Abstract
backgroundIntracerebral hemorrhage (ICH) is characterized by a 30-d mortality rate of 40% and significant disability for those who survive.
objectiveTo investigate the initial safety concerns of histotripsy mediated clot liquefaction and aspiration in a porcine ICH model. Histotripsy is a noninvasive, focused ultrasound technique that generates cavitation to mechanically fractionate tissue. Histotripsy has the potential to liquefy clot in the brain and facilitate minimally invasive aspiration.
methodsAbout 1.75-mL clots were formed in the frontal lobe of the brain (n = 18; n = 6/group). The centers of the clots were liquefied with histotripsy 48 h after formation, and the content was either evacuated or left within the brain. A control group was left untreated. Pigs underwent magnetic resonance imaging (MRI) 7 to 8 d after clot formation and were subsequently euthanized. Neurological behavior was assessed throughout. Histological analysis was performed on harvested brains. A subset of pigs underwent acute analysis (≤6 h).
resultsHistotripsy was able to liquefy the center of clots without direct damage to the perihematomal brain tissue. An average volume of 0.9 ± 0.5 mL was drained after histotripsy treatment. All groups showed mild ischemia and gliosis in the perihematomal region; however, there were no deaths or signs of neurological dysfunction in any groups.
conclusionThis study presents the first analysis of histotripsy-based liquefaction of ICH in vivo. Histotripsy safely liquefies clots without significant additional damage to the perihematomal region. The liquefied content of the clot can be easily evacuated, and the undrained clot has no effect on pig survival or neurological behavior.
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