Evidence map›Paper›PMID 30924397›Full record

Trial reportNeuropsychological rehabilitation2020

Neurocognitive functioning in symptomatic adults with sickle cell disease: A description and comparison with unaffected siblings.

Staci Martin, Marie Claire Roderick, Cristina Abel, Pamela Wolters, Mary Anne Toledo-Tamula, Courtney Fitzhugh, Matthew Hsieh, John Tisdale

Open access · greenAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychological rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  12. SC411 treatment can enhance survival in a mouse model of sickle cell disease.Prostaglandins, leukotrienes, and essential fatty acids · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Staci MartinPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Marie Claire RoderickPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Cristina AbelPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Pamela WoltersPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Mary Anne Toledo-TamulaClinical Research Directorate (CRD), Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Courtney FitzhughMolecular and Clinical Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.
Matthew HsiehMolecular and Clinical Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.
John TisdaleMolecular and Clinical Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.
National Cancer Institute · USNational Heart Lung and Blood Institute · USFrederick National Laboratory for Cancer Research · US

Funding

Nonmyeloablative allogeneic PBSC in globin disordersZIAHL006007 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TISDALE, JOHN · 2009 to 2025
$18.4M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Children and adults with sickle cell disease (SCD) are at risk for neuropsychological deficits; however, the neurocognitive functioning of adults with SCD and related comorbidities has not been widely reported in the literature. We examined specific cognitive domains in symptomatic adults with SCD and compared them with their unaffected siblings. We also examined relationships between cognitive scores, patient-reported outcomes (PROs), and medical/laboratory values. Thirty patient-sibling pairs (

Indexed as

AdultAnemia, Sickle CellAntisickling AgentsCognitive DysfunctionExecutive FunctionFemaleHumansHydroxyureaMaleNeuropsychological TestsPatient Reported Outcome MeasuresSiblingsWechsler ScalesAntisickling AgentsHydroxyureaNeurocognitive functioningProcessing speedSibling controlsSickle cell diseaseSickle cell trait

Identifiers

PMID30924397
PMCPMC8493482
OpenAlexW2928228912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.