ArticleMagnetic resonance in medicine2019
Semi-automated analysis of 4D flow MRI to assess the hemodynamic impact of intracranial atherosclerotic disease.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Uncertainty-aware automated labeling of intracranial arteries using deep learning.BMC medical imaging · 2026Article
- Repeatability and reproducibility of hemodynamic measurements by intracranial 4D Flow MRI: a multi‑vendor and multi‑software cross‑over comparison study.BMC medical imaging · 2025Article
- Non-invasive quantification of pressure drops in stenotic intracranial vessels: using deep learning-enhanced 4D flow MRI to characterize the regional haemodynamics of the pulsing brain.Interface focus · 2025Article
- Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.bioRxiv : the preprint server for biology · 2024Article
- Comparing Vascular Morphology and Hemodynamics in Patients with Vein of Galen Malformations Using Intracranial 4D Flow MRI.AJNR. American journal of neuroradiology · 2024Article
- Interactive effect of hemodynamics in transverse sigmoid sinus and bone morphology on venous pulsatile tinnitus: a four-dimensional (4D) flow magnetic resonance imaging (MRI) study.Quantitative imaging in medicine and surgery · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Randomized Secondary Prevention Trials in Participants With Symptomatic Intracranial Atherosclerotic Stenosis.Stroke · 2024Review
- Automated intracranial vessel segmentation of 4D flow MRI data in patients with atherosclerotic stenosis using a convolutional neural network.Frontiers in radiology · 2024Article
- Pulsatility analysis of the circle of Willis.Aging brain · 2024Article
- Aortic Hemodynamics with Accelerated Dual-Venc 4D Flow MRI in Type B Aortic Dissection.Applied sciences (Basel, Switzerland) · 2023Article
- Estimation of venous sinus pressure drop in patients with idiopathic intracranial hypertension using 4D-flow MRI.European radiology · 2023Article
- Understanding development of jugular bulb stenosis in vein of galen malformations: identifying metrics of complex flow dynamics in the cerebral venous vasculature of infants.Frontiers in physiology · 2023Article
- Raw Materials, Technology, Healthcare Applications, Patent Repository and Clinical Trials on 4D Printing Technology: An Updated Review.Pharmaceutics · 2022Review
- Motion-corrected 4D-Flow MRI for neurovascular applications.NeuroImage · 2022Article
- 4D flow MRI in abdominal vessels: prospective comparison of k-t accelerated free breathing acquisition to standard respiratory navigator gated acquisition.Scientific reports · 2022Article
- Intracranial Blood Flow Quantification by Accelerated Dual-venc 4D Flow MRI: Comparison With Transcranial Doppler Ultrasound.Journal of magnetic resonance imaging : JMRI · 2022Article
- Accelerated dual-venc 4D flow MRI with variable high-venc spatial resolution for neurovascular applications.Magnetic resonance in medicine · 2022Article
- Blood Flow Velocity Pulsatility and Arterial Diameter Pulsatility Measurements of the Intracranial Arteries Using 4D PC-MRI.Neuroinformatics · 2022Article
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8 authors.
Funding
Abstract
purposeThis study evaluated the feasibility of using 4D flow MRI and a semi-automated analysis tool to assess the hemodynamic impact of intracranial atherosclerotic disease (ICAD). The ICAD impact was investigated by evaluating pressure drop (PD) at the atherosclerotic stenosis and changes in cerebral blood flow distribution in patients compared to healthy controls.
methodsDual-venc 4D flow MRI was acquired in 25 healthy volunteers and 16 ICAD patients (ICA, N = 3; MCA, N = 13) with mild (<50%), moderate (50-69%), or severe (>70%) intracranial stenosis. A semi-automated analysis tool was developed to quantify velocity and flow from 4D flow MRI and to evaluate cerebral blood flow redistribution. PD at stenosis was estimated using the Bernoulli equation. The PD calculation was examined by an in vitro phantom study against flow simulations.
resultsFlow analysis in controls indicated symmetry in blood flow rate (FR) and peak velocity (PV) between the brain hemispheres. For patients, PV in the affected hemisphere was significantly (65%) higher than the normal side (P = 0.002). However, FR to both hemispheres of the brain was the same. The PD depicted significant correlation with PV asymmetry in patients (ρ = 0.67 and P = 0.02), and it was significantly higher for severe compared to moderate stenosis (3.73 vs. 2.30 mm Hg, P = 0.02).
conclusion4D flow MRI quantification enables assessment of the hemodynamic impact of ICAD. The significant difference of the PD between patients with severe and moderate stenosis and its correlation with PV asymmetry suggest that PD may be a pertinent hemodynamic biomarker to evaluate ICAD.
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