Evidence map›Paper›PMID 30924180›Full record

ArticleMagnetic resonance in medicine2019

NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-

Jeremy Bancroft Brown, Renuka Sriram, Mark VanCriekinge, Romelyn Delos Santos, Jinny Sun, Justin Delos Santos, Z Laura Tabatabai, Katsuto Shinohara, Hao Nguyen, Donna M Peehl and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jeremy Bancroft BrownDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.ORCID 0000-0002-2537-9059
Renuka SriramDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Mark VanCriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Jinny SunDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Justin Delos SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Z Laura TabatabaiDepartment of Anatomic Pathology, University of California, San Francisco, California.
Katsuto ShinoharaDepartment of Urology, University of California, San Francisco, California.
Hao NguyenDepartment of Urology, University of California, San Francisco, California.
Donna M PeehlDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
University of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Targeting Neuroendocrine Prostate Cancer Using Multi-Probe Hyperpolarized 13C MRI for Improved Treatment and Therapeutic MonitoringR01CA215694 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGGARWAL, RAHUL, KURHANEWICZ, JOHN · 2017 to 2021
$3.3M
NCI NIH HHS R01 CA215694NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

purposeImage-guided prostate biopsies are routinely acquired in the diagnosis and treatment monitoring of prostate cancer, yielding useful tissue for identifying metabolic biomarkers and therapeutic targets. We developed an optimized biopsy tissue culture protocol in combination with [1,6-

methodsWe acquired 34 MRI-ultrasound fusion-guided prostate biopsies in vials on ice from 22 previously untreated patients. Within 15 min, biopsies were transferred to rotary tissue culture in 37°C prostate medium containing [1,6-

resultsLactate concentration in low-grade cancer (1.15 ± 0.78 nmol/mg) and benign (0.74 ± 0.15 nmol/mg) biopsies agreed with prior published measurements of snap-frozen biopsies. There was substantial fractional enrichment of [3-

conclusionA protocol was developed for quantification of lactate production-efflux and TCA cycle activity in single living human prostate biopsies, allowing metabolic labeling on a wide spectrum of human tissues (e.g., metastatic, post-non-surgical therapy) from patients not receiving surgery.

Indexed as

ProstateBiopsyCarbon-13 Magnetic Resonance SpectroscopyCarbon IsotopesGlucoseGlutamic AcidHumansLactic AcidMaleUltrasonographyCarbon IsotopesGlucoseGlutamic AcidLactic Acidbiopsyeffluxlactatemetabolismprostatetracer

Identifiers

PMID30924180
PMCPMC7150535
OpenAlexW2933538596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.