Evidence map›Paper›PMID 30923994›Full record

ArticleWorld journal of microbiology & biotechnology2019

Substrate inactivation of bacterial L-aspartate α-decarboxylase from Corynebacterium jeikeium K411 and improvement of molecular stability by saturation mutagenesis.

Qin Mo, An Mao, Youran Li, Guiyang Shi

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of microbiology & biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Advances in the synthesis of β-alanine.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qin MoNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
An MaoNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Youran LiNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Guiyang ShiNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China. gyshi@jiangnan.edu.cn.
Jiangnan University · CN

Funding

national first-class discipline program of Light Industry Technology and Engineering LITE2018-22Science and Technology Support Program of Jiangsu Province BE2016628the National Natural Foundation of China 31571817the National Science and Technology Major Project 2016YFD0401404
6 · The paper itself

Abstract

Bacterial L-aspartate α-decarboxylase (PanD) is a potential biocatalyst for the green production of β-alanine, an important block chemical for manufacturing nitrogen-containing chemicals in bio-refinery field. It was reported that the poor catalytic stability caused by substrate inactivation limited the large-scale application. Here, we investigated the characters of inactivation by L-aspartate of PanD from Corynebacterium jeikeium (PD

Indexed as

Enzyme StabilityMutagenesis, Site-DirectedAmino Acid SequenceAspartic AcidBacteriabeta-AlanineCarboxy-LyasesCatalytic DomainCorynebacteriumEscherichia coli ProteinsGlutamate DecarboxylaseHigh-Throughput Screening AssaysIndustrial MicrobiologyKineticsSequence AlignmentSubstrate Specificityaspartate-alpha-decarboxylaseAspartic Acidbeta-AlanineCarboxy-LyasesEscherichia coli ProteinsGlutamate DecarboxylasePanD protein, E coliBio-production of β-alanineCatalytic stabilityL-Aspartate α-decarboxylaseSaturation mutagenesisSubstrate inactivationβ-Alanine

Identifiers

PMID30923994
OpenAlexW2927438262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.