Evidence map›Paper›PMID 30923929›Full record

ArticleNanoscale research letters2019

Tailoring Cell Morphomechanical Perturbations Through Metal Oxide Nanoparticles.

Valeria De Matteis, Mariafrancesca Cascione, Chiara Cristina Toma, Paolo Pellegrino, Loris Rizzello, Rosaria Rinaldi

Abstract read
In one paragraph

Article in Nanoscale research letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valeria De MatteisDipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, 73100, Lecce, Italy. valeria.dematteis@unisalento.it.
Mariafrancesca CascioneDipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, 73100, Lecce, Italy.
Chiara Cristina TomaDipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, 73100, Lecce, Italy.
Paolo PellegrinoDipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, 73100, Lecce, Italy.
Loris RizzelloDepartment of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Rosaria RinaldiDipartimento di Matematica e Fisica "Ennio De Giorgi", Università del Salento, Via Arnesano, 73100, Lecce, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nowadays growing use of nanoparticles (NPs) in commercial products does not match a comprehensive understanding of their potential harmfulness. More in vitro investigations are required to address how the physicochemical properties of NPs guide their engulfment within cells and their intracellular trafficking, fate, and toxicity. These nano-bio interactions have not been extensively addressed yet, especially from a mechanical viewpoint. Cell mechanic is a critical indicator of cell health because it regulates processes like cell migration, tissue integrity, and differentiation via cytoskeleton rearrangements. Here, we investigated in vitro the elasticity perturbation of Caco-2 and A549 cell lines, in terms of Young's modulus modification induced by SiO

Indexed as

BiomechanicsCytoskeleton rearrangementsNanoparticlesToxicityYoung’s Modulus

Identifiers

PMID30923929
PMCPMC6439097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.