ArticleAnalytical and bioanalytical chemistry2019
Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor.
Article in Analytical and bioanalytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 91 citations in OpenAlex.
- Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Donor-Acceptor Organic Fluorophores Encapsulated in Polystyrene Nanoparticles as High-Brightness Reporters for Fluorescent Lateral Flow Immunoassay of C-Reactive Protein.Journal of fluorescence · 2026Article
- Recent advances in the biosensing platforms for sepsis diagnosis.RSC advances · 2026Review
- Interface Quality Control of Self-Assembled Monolayer for Highly Sensitive Protein Detection Based on EGOFETs.Sensors (Basel, Switzerland) · 2026Article
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- A Computational Modeling for Reconfigurable Biosensors.BioNanoScience · 2026Article
- Review
- Graphene-Based Opto-Electronic Platform for Ultra-Sensitive Biomarker Detection at Zeptomolar Concentrations.Small methods · 2025Article
- Biosensors based on organic transistors for intraoral biomarker detection.Mikrochimica acta · 2025Review
- Plasmonic Single-Molecule Affinity Detection at 10Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Electric Field Cycling of Physisorbed Antibodies Reduces Biolayer Polarization Dispersion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- ZnO Nanowires/Self-Assembled Monolayer Mediated Selective Detection of Hydrogen.Sensors (Basel, Switzerland) · 2024Article
- Analysis of Clinical Samples of Pancreatic Cyst's Lesions with A Multi-Analyte Bioelectronic Simot Array Benchmarked Against Ultrasensitive Chemiluminescent Immunoassay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ultrafast Biomarker Quantification through Reagentless Capacitive Kinetics.Analytical chemistry · 2023Article
- Organic Bioelectronics Development in Italy: A Review.Micromachines · 2023Review
- Advances in Electrochemical Biosensors Based on Nanomaterials for Protein Biomarker Detection in Saliva.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Promising applications of human-derived saliva biomarker testing in clinical diagnostics.International journal of oral science · 2023Review
- A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing.Science advances · 2022Article
- Why a Diffusing Single-Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.Advanced healthcare materials · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, saliva has been suggested as non-invasive diagnostic fluid, suitable for clinical use alternatively to blood serum and plasma. However, the clinical applicability of saliva has been hampered so far by the inadequate sensitivity of current methods to detect the lower salivary concentrations of many biomarkers monitored in blood products. Herein, a label-free biosensor based on electrolyte-gated organic thin-film transistor (EGOTFT) has been developed for the detection at the physical limit of C-reactive protein (CRP) in human saliva. CRP is a key relevant biomarker for inflammatory processes and is routinely monitored for many clinical purposes. Herein, an electrolyte-gated thin-film transistor (EGOTFT) has been proposed as a transducer of the biorecognition event taking place at the gate electrode, functionalized with a self-assembled monolayer (SAM) of highly densely packed capturing anti-CRP proteins. Thanks to the SAM, the biosensing platform herein proposed is endowed with ultra-high sensitivity, along with an extremely high selectivity, assessed by measuring the dose curves of CRP interacting with a bovine serum albumin-functionalized gate. Moreover, the biosensing platform is compatible with low-cost fabrication techniques and applicable to the ultra-sensitive detection of a plethora of clinically relevant biomarkers. Therefore, the EGOTFT device herein proposed, being able to operate in physiologically relevant fluids such as saliva, will set the ground to a major revolution in biosensing applications for early clinical detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.