ArticleeNeuro
Plasticity of NMDA Receptors at Ventral Hippocampal Synapses in the Infralimbic Cortex Regulates Cued Fear.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- The Involvement of the Endocannabinoid, Glutamatergic, and GABAergic Systems in PTSD.International journal of molecular sciences · 2025Review
- Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction.Molecular brain · 2025Article
- Proteomic insights into extinction memory deficits in stress-susceptible female rats.Frontiers in behavioral neuroscience · 2025Article
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.bioRxiv : the preprint server for biology · 2024Article
- Ventral hippocampal projections to infralimbic cortex and basolateral amygdala are differentially activated by contextual fear and extinction recall.Neurobiology of learning and memory · 2023Article
- The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages.Experimental neurobiology · 2022Review
- Inhibiting ventral hippocampal NMDA receptors andLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex.Frontiers in synaptic neuroscience · 2021Article
- BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model.Behavioural neurology · 2021Article
- Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex.Neurobiology of learning and memory · 2020Review
- Arbitration of Approach-Avoidance Conflict by Ventral Hippocampus.Frontiers in neuroscience · 2020Review
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Authors and funding
6 authors.
Funding
Abstract
The medial prefrontal cortex (mPFC) processes contextual information from the hippocampus to generate appropriate fear responses. In rodents, one path for sending contextual information to the mPFC is via the direct projections from the ventral hippocampus (vHC) to the infralimbic cortex (IL). Plasticity in the synaptic communication from the vHC to the IL could contribute to the behavioral changes produced by the acquisition and extinction of conditioned fear. To examine this possibility, we used optogenetic stimulation of vHC synapses in brain slices from trained rats. We found that fear acquisition reduced NMDA receptor (NMDAR) currents at vHC synapses onto IL pyramidal neurons. The depression of NMDAR currents reversed more efficiently after extinction in the conditioning context than extinction in a novel context. Moreover, a cohort of animals that exhibited poor extinction retrieval failed to reverse the plasticity induced by fear conditioning. In addition, ex vivo application of brain-derived neurotrophic factor (BDNF), which is known to simulate extinction in IL, reversed this conditioning-induced plasticity mimicking extinction. Therefore, we have identified a novel mechanism that modulates conditioned fear via changes in NMDAR current at vHC synapses onto IL pyramidal neurons. Disruption of this mechanism could contribute to the abnormal contextual modulation of fear seen in posttraumatic stress disorder (PTSD).
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