ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
A proteomic signature for dementia with Lewy bodies.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Attitudes and Preferences Towards Screening for Dementia From the Perspectives of Healthcare Professionals: An Updated Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- Precision Medicine for Preventing Alzheimer's Disease: Analysis of the ADAPT Study.Journal of Alzheimer's disease : JAD · 2023Trial
- A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials.Journal of Alzheimer's disease : JAD · 2021Trial
- Intersectional effects of race/ethnicity, sex, and APOE4 on plasma inflammatory profiles in Hispanic and non-Hispanic white adults.Brain, behavior, & immunity - health · 2026Article
- Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins Follistatin and Follistatin-Like Protein-3 With Dementia and Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease.Nature communications · 2023Article
- Plasma Biomarkers of Alzheimer's Disease Are Associated with Physical Functioning Outcomes Among Cognitively Normal Adults in the Multiethnic HABS-HD Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Comorbidities Incorporated to Improve Prediction for Prevalent Mild Cognitive Impairment and Alzheimer's Disease in the HABS-HD Study.Journal of Alzheimer's disease : JAD · 2023Article
- A Blood Screening Test for Dementia with Lewy Bodies for Primary Care.Journal of Alzheimer's disease & Parkinsonism · 2023Article
- Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Proteomic Profiles of Neurodegeneration Among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study.Journal of Alzheimer's disease : JAD · 2022Article
- Parkinson's Disease Blood Test for Primary Care.Journal of Alzheimer's disease & Parkinsonism · 2022Article
- Clinical characteristics of Lewy body dementia in Chinese memory clinics.BMC neurology · 2021Article
- Recursive Support Vector Machine Biomarker Selection for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.Nature reviews. Neurology · 2020Review
- Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
introductionWe sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with Lewy bodies (DLB) from Parkinson's disease (PD).
methodsStored plasma samples were obtained from 145 patients (DLB n = 57, PD without dementia n = 32, normal controls n = 56) enrolled from patients seen in the Behavioral Neurology or Movement Disorders clinics at the Mayo Clinic, Florida. Proteomic assays were conducted and analyzed as per our previously published protocols.
resultsIn the first step, the proteomic profile distinguished the DLB-PD group from controls with a diagnostic accuracy of 0.97, sensitivity of 0.91, and specificity of 0.86. In the second step, the proteomic profile distinguished the DLB from PD groups with a diagnostic accuracy of 0.92, sensitivity of 0.94, and specificity of 0.88. DISCUSSION: These data provide evidence of the potential utility of a multitiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from PD.
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