Evidence map›Paper›PMID 30923729›Full record

ArticleTranslational perioperative and pain medicine2019

The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome.

Sophia Koutsogiannaki, Motomu Shimaoka, Koichi Yuki

Registry-linked trialAbstract read
In one paragraph

Article in Translational perioperative and pain medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05559970 (Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05559970 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients: a Pilot Open-label Randomized Controlled Study

TypeinterventionalSponsorMahidol UniversityRan2022 to 2024Enrolled40ConditionsMechanical Ventilation, Sedation, Mechanical Power, Lung InjuryArmsInhalational sedation, Convention sedation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. COVID-19 pathophysiology: A review.Clinical immunology (Orlando, Fla.) · 2020
    Review
  8. Translational perioperative and pain medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sophia KoutsogiannakiDepartment of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA.
Motomu ShimaokaDepartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsushi, Mie, Japan.
Koichi YukiDepartment of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA.

Funding

The impact of anesthetic selection on sepsis outcome and its mechanismR01GM118277 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2016 to 2020
$1.8M
NIGMS NIH HHS R01 GM118277
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) remains to pose a high morbidity and mortality without any targeted therapies. Sedation, usually given intravenously, is an important part of clinical practice in intensive care unit (ICU), and the effect of sedatives on patients' outcomes has been studied intensively. Although volatile anesthetics are not routine sedatives in ICU, preclinical and clinical studies suggested their potential benefit in pulmonary pathophysiology. This review will summarize the current knowledge of ARDS and the role of volatile anesthetic sedation in this setting from both clinical and mechanistic standpoints. In addition, we will review the infrastructure to use volatile anesthetics.

Identifiers

PMID30923729
PMCPMC6433148

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.