Evidence map›Paper›PMID 30923725›Full record

ArticleOrthopaedic journal of sports medicine2019

Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study.

Martha M Murray, Leslie A Kalish, Braden C Fleming, BEAR Trial Team, Brett Flutie, Christina Freiberger, Rachael N Henderson, Gabriel S Perrone, Laura G Thurber, Benedikt L Proffen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 5 pooled it
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 5 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  5. Reduced knee laxity and failure rate following anterior cruciate ligament reconstruction compared with repair for acute tears: a meta-analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023
    Pooled it
  6. Trial
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  13. Postcommercialisation outcomes of bridge-enhanced anterior cruciate ligament restoration: The first 100 Bridge registry patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Martha M MurrayInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Leslie A KalishInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Braden C FlemingInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
BEAR Trial Team
Brett FlutieInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Christina FreibergerInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Rachael N HendersonInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Gabriel S PerroneInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Laura G ThurberInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Benedikt L ProffenInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Kirsten EcklundInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Dennis E KramerInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Yi-Meng YenInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Lyle J MicheliInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · US

Funding

Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
Non-invasive Assessment of Ligament Healing, in VivoR01AR065462 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2014 to 2016
$2.1M
NIAMS NIH HHS R01 AR056834NIAMS NIH HHS R01 AR065462
6 · The paper itself

Abstract

backgroundBridge-enhanced anterior cruciate ligament repair (BEAR) combines suture repair of the anterior cruciate ligament (ACL) with a specific extracellular matrix scaffold (the BEAR scaffold) that is placed in the gap between the torn ends of the ACL to facilitate ligament healing. PURPOSE/HYPOTHESIS: The purpose of this study was to report the 12- and 24-month outcomes of patients who underwent the BEAR procedure compared with a nonrandomized concurrent control group who underwent ACL reconstruction (ACLR) with an autograft. We hypothesized that the BEAR group would have physical examination findings, patient-reported outcomes, and adverse events that were similar to those of the ACLR group. STUDY

designCohort study; Level of evidence, 2.

methodsTen patients underwent BEAR, and 10 underwent ACLR with a 4-stranded hamstring autograft. At 24 months, 9 of the 10 BEAR patients and 7 of the 10 ACLR patients completed a study visit. Outcomes reported included International Knee Documentation Committee (IKDC) subjective and objective results, knee anteroposterior (AP) laxity findings via an arthrometer, and functional outcomes.

resultsThere were no graft or repair failures in the first 24 months after surgery. The IKDC subjective scores in both groups improved significantly from baseline (

conclusionIn this small, first-in-human study, BEAR produced similar outcomes to ACLR with a hamstring autograft. BEAR may result in knee stability and patient-reported outcomes at 2 years sufficient to warrant longer term studies of efficacy in larger groups of patients.

Indexed as

ACL reconstructionACL repairanterior cruciate ligamentBEARbridge-enhanced ACL repairhuman

Identifiers

PMID30923725
PMCPMC6431773
OpenAlexW2942523230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.