ArticleNature biomedical engineering2019
Combinatorial interactions of genetic variants in human cardiomyopathy.
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Article in Nature biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
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- Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy.Frontiers in bioinformatics · 2026Article
- A combined genomic arrhythmia propensity score delineates cumulative risk.Cell reports. Medicine · 2025Article
- Transformative Potential of Induced Pluripotent Stem Cells in Congenital Heart Disease Research and Treatment.Children (Basel, Switzerland) · 2025Review
- Vinculin haploinsufficiency impairs integrin-mediated costamere remodeling on stiffer microenvironments.Journal of molecular and cellular cardiology · 2025Article
- Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development.Cell genomics · 2024Article
- ExEmPLAR (Extracting, Exploring, and Embedding Pathways Leading to Actionable Research): a user-friendly interface for knowledge graph mining.Bioinformatics (Oxford, England) · 2024Article
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- Learnings from the 2024 Utah Cardiac Recovery Symposium: A Roadmap for the Field of Myocardial Recovery.Methodist DeBakey cardiovascular journal · 2024Article
- End-stage Hypertrophic Cardiomyopathy with Advanced Heart Failure in Patients Carrying MYH7 R453 Variants: A Case Series.Internal medicine (Tokyo, Japan) · 2023Article
- Association of rs35006907 Polymorphism with Risk of Dilated Cardiomyopathy in Han Chinese Population.Balkan journal of medical genetics : BJMG · 2023Article
- Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier.JACC. Basic to translational science · 2023Article
- Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy.Disease models & mechanisms · 2023Article
- Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery.Stem cell reports · 2023Article
- Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play.Frontiers in cardiovascular medicine · 2023Review
- 3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease.Frontiers in cardiovascular medicine · 2023Article
- Prospective Advances in Genome Editing Investigation.Advances in experimental medicine and biology · 2023Article
- Human-gained heart enhancers are associated with species-specific cardiac attributes.Nature cardiovascular research · 2022Article
- Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model.Animals : an open access journal from MDPI · 2022Review
- CRISPR Modeling and Correction of Cardiovascular Disease.Circulation research · 2022Review
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Dekker C Deacon *Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Cassandra L Happe *Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Chao Chen *Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Neil TedeschiDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ana Maria MansoDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ting LiDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Nancy D DaltonDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Qian PengDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2662-3412
Elie N FarahDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yusu GuDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kevin P TenerelliDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Vivien D TranDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Ju ChenDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kirk L PetersonDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Nicholas J SchorkDepartment of Human Biology, J. Craig Venter Institute, La Jolla, CA, USA.
Eric D AdlerDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Adam J EnglerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA. aengler@ucsd.edu.ORCID http://orcid.org/0000-0003-1642-5380
Robert S RossDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. rross@ucsd.edu.ORCID http://orcid.org/0000-0003-2195-8982
Neil C ChiDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. nchi@ucsd.edu.ORCID http://orcid.org/0000-0003-2324-3796
University of California San Diego · USUnited States Department of Veterans Affairs · USJ. Craig Venter Institute · USScripps Research Institute · US
Funding
Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics ConsortiaU01HL131003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, OLLBERDING, NICHOLAS J · 2016 to 2024
$54.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MTraining Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6MDevelopmental Regulatory Genomics of Human Cardiovascular LineagesUM1HL128773 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, EVANS, SYLVIA M · 2015 to 2019
$3.8MMechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionR01AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2013 to 2022
$3.4MThe Cardiac Role of Filamin CR01HL144872 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6MALPK3 in cardiac function and diseaseR01HL146759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6MThe role of Nexilin in cardiomyocyte and cardiomyopathyR01HL137957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2017 to 2020
$1.6MBAG3 in Cardiac function and diseaseR01HL130295 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2016 to 2019
$1.6MCardiac Myocyte Form and Function: Role of Talin and KindlinR01HL127806 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSS, ROBERT SCOTT · 2015 to 2018
$1.6MBig data analytics for the evaluation of whole genome sequence and transcriptome data in alcohol researchK25AA025095 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI PENG, QIAN · 2016 to 2020
$807kBLRD VA I01 BX003260NHLBI NIH HHS F32 HL131424NHLBI NIH HHS R01 HL127806NHLBI NIH HHS R01 HL130295NHLBI NIH HHS R01 HL137957NHLBI NIH HHS R01 HL144872NHLBI NIH HHS R01 HL146759NHLBI NIH HHS T32 HL007444NHLBI NIH HHS U01 HL131003NHLBI NIH HHS UM1 HL128773NIAAA NIH HHS K25 AA025095NIA NIH HHS R01 AG045428NIGMS NIH HHS T32 GM007198NIGMS NIH HHS T32 GM008666
Abstract
Dilated cardiomyopathy (DCM) is a leading cause of morbidity and mortality worldwide; yet how genetic variation and environmental factors impact DCM heritability remains unclear. Here, we report that compound genetic interactions between DNA sequence variants contribute to the complex heritability of DCM. By using genetic data from a large family with a history of DCM, we discovered that heterozygous sequence variants in the
Indexed as
Genetic Predisposition to DiseaseGenetic VariationAnimalsCardiomyopathy, DilatedExtracellular MatrixFemaleGene Expression RegulationHumansInheritance PatternsMaleMiceModels, BiologicalMuscle ContractionMyocytes, CardiacPedigreePluripotent Stem Cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.