ArticleTherapeutic advances in neurological disorders2019
Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson's disease.
Article in Therapeutic advances in neurological disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging.International journal of molecular sciences · 2026Review
- Friend or foe? Glial-vascular interactions in health and neurodegenerative disease.Pharmacological reviews · 2026Review
- Review
- Cerebrovascular Reactivity Assessment with Breath-Hold Functional MRI in Patients with Moyamoya Angiopathy: Which Time Period to Analyze?Diagnostics (Basel, Switzerland) · 2026Article
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Dynamic cerebral autoregulation impairment in patients with Parkinson's disease correlates with autonomic disfunction.BMC neurology · 2026Article
- Elevated cerebral oxygen extraction fraction in Parkinson's disease correlates with motor impairment severity.Scientific reports · 2026Article
- Article
- Hemodynamic subtype profiling in tremor-dominant and akinetic-rigid Parkinson's disease using multi-delay pseudo-continuous arterial spin labeling imaging.Frontiers in human neuroscience · 2025Article
- Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.Magnetic resonance in medicine · 2024Review
- Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2024Review
- Assessment of brainstem function and haemodynamics by MRI: challenges and clinical prospects.The British journal of radiology · 2023Review
- Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Cerebral blood flow regulates iron overload in the cerebral nuclei of hemodialysis patients with anemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Altered Cerebral Vasoreactivity on Transcranial Color-Coded Sonography Related to Akinetic-Rigid Phenotype of Parkinson's Disease: Interim Analysis of a Cross-Sectional Study.Brain sciences · 2023Article
- Neural control of cerebral blood flow: scientific basis of scalp acupuncture in treating brain diseases.Frontiers in neuroscience · 2023Review
- Whole-Head Functional Near-Infrared Spectroscopy as an Ecological Monitoring Tool for Assessing Cortical Activity in Parkinson's Disease Patients at Different Stages.International journal of molecular sciences · 2022Article
- Cerebral blood flow dependency on systemic arterial circulation in progressive multiple sclerosis.European radiology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is a progressive neurodegenerative disorder that is mainly characterized by movement dysfunction. Neurovascular unit (NVU) disruption has been proposed to be involved in the disease, but its role in PD neurodegenerative mechanisms is still unclear. The aim of this study was to investigate cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within the regions belonging to the motor network, in patients with mild to moderate stages of PD.
methodsTwenty-eight PD patients (66.6 ± 8.6 years, 22 males, median [interquartile range, IQR] Hoehn & Yahr = 1.5 [1-1.9]) and 32 age- and sex-matched healthy controls (HCs) were scanned with arterial spin labeling (ASL) magnetic resonance imaging (MRI) for CBF assessment. ASL MRI was also acquired in hypercapnic conditions to induce vasodilation and subsequently allow for CVR measurement in a subgroup of 13 PD patients and 13 HCs. Median CBF and CVR were extracted from cortical and subcortical regions belonging to the motor network and compared between PD patients and HCs. In addition, the correlation between these parameters and the severity of PD motor symptoms [quantified with Unified Parkinson's Disease Rating Scale part III (UPDRS III)] was assessed. The false discovery rate (FDR) method was used to correct for multiple comparisons.
resultsNo significant differences in terms of CBF and CVR were found between PD patients and HCs. Positive significant correlations were observed between CBF and UPDRS III within the precentral gyrus, postcentral gyrus, supplementary motor area, striatum, pallidum, thalamus, red nucleus, and substantia nigra (pFDR < 0.05). Conversely, significant negative correlation between CVR and UPDRS III was found in the corpus striatum (pFDR < 0.05).
conclusionCBF and CVR assessment provides information about NVU integrity in an indirect and noninvasive way. Our findings support the hypothesis of NVU involvement at the mild to moderate stages of PD, suggesting that CBF and CVR within the motor network might be used as either diagnostic or prognostic markers for PD.
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