Evidence map›Paper›PMID 30923521›Full record

ArticleFrontiers in immunology2019

Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum.

Jayaum S Booth, Seema A Patil, Eric Goldberg, Robin S Barnes, Bruce D Greenwald, Marcelo B Sztein

Open access · goldAbstract readControlled Clinical Trial
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jayaum S BoothCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Seema A PatilDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Eric GoldbergDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Robin S BarnesCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Bruce D GreenwaldDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · US

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, JUDITH M. · 2003 to 2013
$91.5M
Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRASER, CLAIRE M. · 2009 to 2018
$27.8M
Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
NIAID NIH HHS R01 AI036525NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI109776NIAID NIH HHS U54 AI057168
6 · The paper itself

Abstract

Tissue-resident memory T cells (T

Indexed as

Administration, OralAgedCD8-Positive T-LymphocytesFemaleHumansIleumIntestinal MucosaMaleMiddle AgedPolysaccharides, BacterialT-Lymphocyte SubsetsTyphoid-Paratyphoid VaccinesPolysaccharides, BacterialTy21a typhoid vaccineTyphoid-Paratyphoid VaccinesIEL intraepithelial lymphocyteslamina propria mononuclear cellsLPMCmucosal immune responsesS. Typhiterminal ileumtissue resident memory CD8+ T

Identifiers

PMID30923521
PMCPMC6426796
OpenAlexW2920929714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.