ArticleActa histochemica et cytochemica2019
The Role of the Wnt Signaling Pathway in Upper Jaw Development of Chick Embryo.
Article in Acta histochemica et cytochemica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Single-cell transcriptome and chromatin accessibility mapping of upper lip and primary palate fusion.Journal of cellular and molecular medicine · 2024Article
- Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review.Journal of personalized medicine · 2023Article
- miR-29a Is Downregulated in Progenies Derived from Chronically Stressed Males.International journal of molecular sciences · 2023Article
- Immunohistochemical Evaluation of BARX1, DLX4, FOXE1, HOXB3, and MSX2 in Nonsyndromic Cleft Affected Tissue.Acta medica Lituanic · 2022Article
- Transcriptomic Analysis of Laying Hens Revealed the Role of Aging-Related Genes during Forced Molting.Genes · 2021Article
- Co-occurrence of orofacial clefts and clubfoot phenotypes in a sub-Saharan African cohort: Whole-exome sequencing implicates multiple syndromes and genes.Molecular genetics & genomic medicine · 2021Article
- Article
- Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism.Genesis (New York, N.Y. : 2000) · 2020Article
- Genetics and signaling mechanisms of orofacial clefts.Birth defects research · 2020Review
- Molecular Diagnostics and In Utero Therapeutics for Orofacial Clefts.Journal of dental research · 2020Review
- ceRNA network development and tumour-infiltrating immune cell analysis of metastatic breast cancer to bone.Journal of bone oncology · 2020Article
- Structure identification, antitumor activity and mechanisms of a novel polysaccharide fromOncology letters · 2020Article
- Fatty Acid Binding Protein 7 is Involved in the Proliferation of Reactive Astrocytes, but not in Cell Migration and Polarity.Acta histochemica et cytochemica · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cleft lip with or without cleft palate (CLP) usually results from a failure of the medial nasal prominences to fuse with the lateral and maxillary prominences. This failure inhibits facial morphogenesis regulated by several major morphogenetic signaling pathways. We hypothesized that CLP results from the failure of the Wnt signaling pathway. To examine whether Wnt signaling can influences upper jaw development, we applied beads soaked with Dickkopf-1 (Dkk-1), Alsterpaullone (AL) or Wnt3a to the right side of the maxillary prominence of the chick embryo. The embryo showed a defect of the maxilla on the treated side, and skeletal staining revealed hypoplasia of the premaxilla and palatine bone as a result of Dkk-1-soaked bead implantation. 5-bromo-2'-deoxyuridine (BrdU)-positive cell numbers in the treated maxillary prominence were significantly lower at both 24 and 48 hr after implantation. Down-regulation of the expression of
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