ArticleScience (New York, N.Y.)2019
Remembered reward locations restructure entorhinal spatial maps.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed.
- Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.Nature neuroscience · 2026Article
- Subicular plateaus signal reward locations during goal-directed behavior.Cell reports · 2026Article
- Transformations of the spatial activity manifold convey aversive information in CA3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Grid maps are disrupted after large-scale arena expansion and recover with experience.Nature communications · 2026Article
- Article
- Action information is integrated into entorhinal representations of conceptual space and is reflected in eye movements.PLoS biology · 2026Article
- Directional dynamics in the entorhinal cortex of male mice driven by behavioral constraints.Nature communications · 2026Article
- Gaussian Process Inference Reveals Non-separability of Position and Velocity Tuning in Grid Cells.bioRxiv : the preprint server for biology · 2026Article
- Subicular Plateaus Signal Reward Locations during Goal-Directed Behavior.bioRxiv : the preprint server for biology · 2026Article
- Reproducible and predictable reorganization of place fields driven by grid subfield rate changes.bioRxiv : the preprint server for biology · 2026Article
- Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment.bioRxiv : the preprint server for biology · 2026Article
- Activation of the medial entorhinal cortex drives memory-guided navigation behavior.bioRxiv : the preprint server for biology · 2025Article
- Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells.bioRxiv : the preprint server for biology · 2025Article
- Reward history alters priority map based on spatial relationship, but not absolute location.Psychonomic bulletin & review · 2025Article
- Grid cells accurately track movement during path integration-based navigation despite switching reference frames.Nature neuroscience · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Reconciling flexibility and efficiency: medial entorhinal cortex represents a compositional cognitive map.Nature communications · 2025Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice.Nature communications · 2025Article
- Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.eLife · 2025Article
34 more citing papers are in PubMed but not listed here.
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Abstract
Ethologically relevant navigational strategies often incorporate remembered reward locations. Although neurons in the medial entorhinal cortex provide a maplike representation of the external spatial world, whether this map integrates information regarding learned reward locations remains unknown. We compared entorhinal coding in rats during a free-foraging task and a spatial memory task. Entorhinal spatial maps restructured to incorporate a learned reward location, which in turn improved positional decoding near this location. This finding indicates that different navigational strategies drive the emergence of discrete entorhinal maps of space and points to a role for entorhinal codes in a diverse range of navigational behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.