ArticleThe European respiratory journal2019
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents.
Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Loss of Rab44 attenuates ovalbumin-induced allergic airway inflammation by modulating immune responses and eosinophil function.Frontiers in immunology · 2026Article
- Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.Genome medicine · 2025Article
- EMixed: Probabilistic Multi-Omics Cellular Deconvolution of Bulk Omics Data.Journal of data science : JDS · 2025Article
- MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.Clinical epigenetics · 2024Article
- Impaired Development of Collagen Antibody-Induced Arthritis in Rab44-Deficient Mice.Biomedicines · 2024Article
- Molecular group and correlation guided structural learning for multi-phenotype prediction.Briefings in bioinformatics · 2024Article
- Beyond type 2 asthma biomarkers: risk stratification for NSAID-exacerbated respiratory disease.ERJ open research · 2024Article
- Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.The Journal of allergy and clinical immunology · 2024Article
- Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers.Genome medicine · 2023Article
- Construction and verification of atopic dermatitis diagnostic model based on pyroptosis related biological markers using machine learning methods.BMC medical genomics · 2023Article
- Timing of Blood Sample Processing Affects the Transcriptomic and Epigenomic Profiles in CD4Cells · 2022Article
- Peripheral blood transcriptomic clusters uncovered immune phenotypes of asthma.Respiratory research · 2022Article
- Robust and accurate estimation of cellular fraction from tissue omics data via ensemble deconvolution.Bioinformatics (Oxford, England) · 2022Article
- Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.The European respiratory journal · 2022Article
- Large Rab GTPases: Novel Membrane Trafficking Regulators with a Calcium Sensor and Functional Domains.International journal of molecular sciences · 2021Review
- Digital Health Europe (DHE) Twinning on severe asthma-kick-off meeting report.Journal of thoracic disease · 2021Article
- A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents.Allergy · 2020Article
- Childhood asthma in the new omics era: challenges and perspectives.Current opinion in allergy and clinical immunology · 2020Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 6 countries.
Funding
Abstract
Early allergic sensitisation (atopy) is the first step in the development of allergic diseases such as atopic asthma later in life. Genes and pathways associated with atopy and atopic asthma in children and adolescents have not been well characterised.A transcriptome-wide association study (TWAS) of atopy and atopic asthma in white blood cells (WBCs) or whole blood was conducted in a cohort of 460 Puerto Ricans aged 9-20 years (EVA-PR study) and in a cohort of 250 Swedish adolescents (BAMSE study). Pathway enrichment and network analyses were conducted to further assess top findings, and classification models of atopy and atopic asthma were built using expression levels for the top differentially expressed genes (DEGs).In a meta-analysis of the study cohorts, both previously implicated genes (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.