ArticleGenetics2019
The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- Estimating the additive genetic variance for relative fitness from changes in allele frequency.Genetics · 2026Article
- A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads.Genetics · 2025Article
- A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads.bioRxiv : the preprint server for biology · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- Whole-Genome Sequencing Reveals the Progress of Genetic Breeding inAnimals : an open access journal from MDPI · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- The fitness consequences of genetic divergence between polymorphic gene arrangements.Genetics · 2024Article
- Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.Genome biology and evolution · 2024Article
- The Effects of Mutation and Recombination Rate Heterogeneity on the Inference of Demography and the Distribution of Fitness Effects.Genome biology and evolution · 2024Article
- Evolution of a plant sex chromosome driven by expanding pericentromeric recombination suppression.Scientific reports · 2024Article
- Pericentromeric recombination suppression and the 'large X effect' in plants.Scientific reports · 2023Article
- Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.Evolution; international journal of organic evolution · 2023Article
- Article
- Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.bioRxiv : the preprint server for biology · 2023Article
- A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility.Genome research · 2022Article
- impMKT: the imputed McDonald and Kreitman test, a straightforward correction that significantly increases the evidence of positive selection of the McDonald and Kreitman test at the gene level.G3 (Bethesda, Md.) · 2022Review
- Article
- Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- How Can We Resolve Lewontin's Paradox?Genome biology and evolution · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Levels of variability and rates of adaptive evolution may be affected by hitchhiking, the effect of selection on evolution at linked sites. Hitchhiking can be caused either by "selective sweeps" or by background selection, involving the spread of new favorable alleles or the elimination of deleterious mutations, respectively. Recent analyses of population genomic data have fitted models where both these processes act simultaneously, to infer the parameters of selection. Here, we investigate the consequences of relaxing a key assumption of some of these studies, that the time occupied by a selective sweep is negligible compared with the neutral coalescent time. We derive a new expression for the expected level of neutral variability in the presence of recurrent selective sweeps and background selection. We also derive approximate integral expressions for the effects of recurrent selective sweeps. The accuracy of the theoretical predictions was tested against multilocus simulations, with selection, recombination, and mutation parameters that are realistic for
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.