Evidence map›Paper›PMID 30923128›Full record

ArticleThe Journal of biological chemistry2019

A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.

Zhiyi Yu, David C Chiara, Pavel Y Savechenkov, Karol S Bruzik, Jonathan B Cohen

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiyi YuFrom the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115 and.
David C ChiaraFrom the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115 and.
Pavel Y Savechenkovthe Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612.
Karol S Bruzikthe Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612.
Jonathan B CohenFrom the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115 and jonathan_cohen@hms.harvard.edu.

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI COHEN, JONATHAN BREWER · 1999 to 2018
$33.6M
NIGMS NIH HHS P01 GM058448
6 · The paper itself

Abstract

Many neuroactive steroids potently and allosterically modulate pentameric ligand-gated ion channels, including GABA

Indexed as

Molecular Docking SimulationPregnanoloneAnimalsBinding SitesFish ProteinsReceptors, NicotinicSteroidsTetracaineTorpedoFish ProteinsPregnanoloneReceptors, NicotinicSteroidsTetracaineanestheticGABA receptorion channelligand-gated ion channellipid–protein interactionneurosteroid allopregnanoloneneurotransmitter receptornicotinic acetylcholine receptors (nAChR)perfluorophenyl azidephotolabelingsteroid

Identifiers

PMID30923128
PMCPMC6514614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.