ArticleProceedings of the National Academy of Sciences of the United States of America2019
Macroscale intrinsic network architecture of the hypothalamus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- The last-step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract.The Journal of physiology · 2026Review
- Efferent projections of topographically distinct relaxin family peptide receptor-3 (RXFP3) lateral hypothalamus/zona incerta cells.Brain structure & function · 2026Article
- Intrinsic neuronal network organization of a mammalian peripheral nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Differences in Colour Pattern, Behaviour and Gene Expression in the Brain Suggest Divergent Camouflage Strategies in Sympatric Reef Fish Species.Molecular ecology · 2025Article
- Projectome-based characterization of hypothalamic peptidergic neurons in male mice.Nature neuroscience · 2025Article
- Hypothalamic GABAergic neurons: their roles in health and metabolic diseases.Frontiers in endocrinology · 2025Review
- Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat.bioRxiv : the preprint server for biology · 2024Article
- Neural network architecture of a mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Brain Mechanisms Underlying Panic Attack and Panic Disorder.Neuroscience bulletin · 2024Review
- Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector).Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The neuroanatomical organization of the hypothalamus is driven by spatial and topological efficiency.Frontiers in systems neuroscience · 2024Article
- Intrinsic circuitry of the rhombicbrain (central nervous system's intermediate sector) in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus.Science advances · 2023Article
- Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics.Nature methods · 2023Article
- Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cellular Localization of Orexin 1 Receptor in Human Hypothalamus and Morphological Analysis of Neurons Expressing the Receptor.Biomolecules · 2023Article
- Populational heterogeneity and partial migratory origin of the ventromedial hypothalamic nucleus: genoarchitectonic analysis in the mouse.Brain structure & function · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Control of multiple life-critical physiological and behavioral functions requires the hypothalamus. Here, we provide a comprehensive description and rigorous analysis of mammalian intrahypothalamic network architecture. To achieve this at the gray matter region (macroscale) level, macroscale connection (macroconnection) data for the rat hypothalamus were extracted from the primary literature. The dataset indicated the existence of 7,982 (of 16,770 possible) intrahypothalamic macroconnections. Network analysis revealed that the intrahypothalamic macroconnection network (its macroscale subconnectome) is divided into two identical top-level subsystems (or subnetworks), each composed of two nested second-level subsystems. At the top-level, this suggests a deeply integrated network; however, regional grouping of the two second-level subsystems suggested a partial separation between control of physiological functions and behavioral functions. Furthermore, inclusion of four candidate hubs (dominant network nodes) in the second-level subsystem that is associated prominently with physiological control suggests network primacy with respect to this function. In addition, comparison of network analysis with expression of gene markers associated with inhibitory (GAD65) and excitatory (VGLUT2) neurotransmission revealed a significant positive correlation between measures of network centrality (dominance) and the inhibitory marker. We discuss these results in relation to previous understandings of hypothalamic organization and provide, and selectively interrogate, an updated hypothalamus structure-function network model to encourage future hypothesis-driven investigations of identified hypothalamic subsystems.
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