Evidence map›Paper›PMID 30922901›Full record

ArticleWorld neurosurgery2019

Machine Learning for the Prediction of Cervical Spondylotic Myelopathy: A Post Hoc Pilot Study of 28 Participants.

Benjamin S Hopkins, Kenneth A Weber, Kartik Kesavabhotla, Monica Paliwal, Donald R Cantrell, Zachary A Smith

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in World neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05099627 (A Point-of-care Machine Learning Model and Scoring System for the Early Diagnosis and Prediction of Treatment Outcome in Patients With Cervical Myelopathy), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05099627 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Point-of-care Machine Learning Model and Scoring System for the Early Diagnosis and Prediction of Treatment Outcome in Patients With Cervical Myelopathy: an Ambispective Cohort Study.

TypeobservationalSponsorImperial College Healthcare NHS TrustRan2021 to 2022Enrolled300ConditionsCervical MyelopathyArmsThe questionnaire "Cervical myelopathy treatment outcome questionnaire", The retrospective questionnaire "CSM early diagnosis questionnaire", JOACMEQ questionnaire and mJOA
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  3. Degenerative cervical myelopathy diagnosis: applicability of artificial intelligence-enhanced modalities in a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin S HopkinsDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kenneth A WeberDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Kartik KesavabhotlaDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Monica PaliwalDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Donald R CantrellDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Zachary A SmithDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: zsmith1@nm.org.
Northwestern University · USStanford University · US

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
Radiographic markers of clinical function in Cervical Spondylotic MyelopathyK23NS091430 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SMITH, ZACHARY · 2017 to 2021
$1.1M
Neuroimaging-Based Brain and Spinal Cord Biomarkers for Cervical RadiculopathyK23NS104211 · NINDS · STANFORD UNIVERSITY · PI WEBER, KENNETH ARNOLD · 2018 to 2022
$875k
NIDA NIH HHS T32 DA035165NINDS NIH HHS K23 NS091430NINDS NIH HHS K23 NS104211NINDS NIH HHS L30 NS108301
6 · The paper itself

Abstract

backgroundCervical spondylotic myelopathy (CSM) severity and presence of symptoms are often difficult to predict based simply on clinical imaging alone. Similarly, improved machine learning techniques provide new tools with immense clinical potential.

methodsA total of 14 patients with CSM and 14 controls underwent imaging of the cervical spine. Two different artificial neural network models were trained; 1) to predict CSM diagnosis; and 2) to predict CSM severity. Model 1 consisted of 6 inputs including 3 common imaging scales for the evaluation of cord compression, alongside 3 objective magnetic resonance imaging measurements. The outcome for model 1 was binary to predict CSM diagnosis. Model 2 consisted of 23 input variables derived from probabilistic volume mapping measurements of white matter tracts in the region of compression. The outcome of model 2 was linear, to predict the modified Japanese Orthopedic Association (mJOA) score.

resultsModel 1 was used in predicting CSM. The mean cross-validated accuracy of the trained model was 86.50% (95% confidence interval, 85.16%-87.83%) with a median accuracy of 90.00%. Area under the curve (AUC) was calculated for each repetition. Average AUC for each repetition was 0.947 with a median AUC of 1.0. Average sensitivity, specificity, positive predictive value, and negative predictive value were 90.25%, 85.05%, 81.58%, and 91.94%, respectively. Model 2 was used in modeling mJOA. The mJOA model predicted scores, with a mean and median error of -0.29 mJOA points and -0.08 mJOA points, respectively, mean error per batch was 0.714 mJOA points.

conclusionsMachine learning provides a promising method for prediction, diagnosis, and even prognosis in patients with CSM.

Indexed as

Machine LearningAdultAgedCervical VertebraeFemaleHumansMaleMiddle AgedPilot ProjectsPrognosisSpinal Cord CompressionSpinal Cord DiseasesSpondylosisTreatment OutcomeArtificial intelligenceCervical myelopathyCervical spondylotic myelopathyCSMMachine learningSpine

Identifiers

PMID30922901
PMCPMC6610711
OpenAlexW2923067190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.