ArticleNeuron2019
A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
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Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 296 papers.
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296citing papers in PubMed
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296 citing papers in PubMed, 576 citations in OpenAlex.
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- Chemigenetic DNA nanotrap for the mapping of norepinephrine in subcellular organelles.Nature chemical biology · 2026Article
- In vivo multimodal neurochemical interfaces for real-time decoding of brain circuit.Nature reviews. Neuroscience · 2026Review
236 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 11 institutions in 3 countries.
Jiesi FengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Changmei ZhangInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Julieta E LischinskyNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Miao JingState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Chinese Institute for Brain Research, Beijing 100871, China.
Jingheng ZhouNeurobiology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Huan WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Yajun ZhangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Ao DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Zhaofa WuState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Hao WuState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Weiyu ChenInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Peng ZhangDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jing ZouDepartment of Biological Sciences, Neurobiology Section, University of Southern California, Los Angeles, CA 90089, USA.
S Andrew HiresDepartment of Biological Sciences, Neurobiology Section, University of Southern California, Los Angeles, CA 90089, USA.
J Julius ZhuDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; School of Medicine, Ningbo University, Ningbo 315010, China; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, 6525 Nijmegen, the Netherlands; Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Guohong CuiNeurobiology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Dayu LinNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10016, USA.
Jiulin DuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Chinese Institute for Brain Research, Beijing 100871, China. Electronic address: yulongli@pku.edu.cn.
Chinese Institute for Brain Research · CNNational Institute of Environmental Health Sciences · USNew York University · USUniversity of Chinese Academy of Sciences · CNUniversity of Southern California · USCenter for Life Sciences · CNChinese Academy of Sciences · CNHuazhong University of Science and Technology · CNPeking University · CNTsinghua University · CNUniversity of Virginia · US
Funding
Basal Ganglia in Health and DiseaseZIAES103310 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUI, GUOHONG · 2016 to 2025
$23.6MThalamic Modulation of Auditory Cortical Processing via LPR01DC008983 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Li I Zhang · 2007 to 2026
$8.7MResearch Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6MNovel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2MGenetically-encoded ACh sensorsR01NS104670 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2018 to 2022
$2.2MCalcium channel and glutamate receptor signaling at synapsesR01NS091452 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7MSynaptic Depression: Focus on Cdk5 SignalingR01NS092548 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7MInvestigating the neural mechanism of maternal motivationR21HD090563 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2019
$466kIntramural NIH HHS ZIA ES103310NICHD NIH HHS R21 HD090563NIDCD NIH HHS R01 DC008983NIMH NIH HHS R01 MH101377NINDS NIH HHS R01 NS091452NINDS NIH HHS R01 NS092548NINDS NIH HHS R01 NS104670NINDS NIH HHS U01 NS103558
Abstract
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide range of physiological processes. However, its precise dynamics and regulation remain poorly characterized, in part due to limitations of available techniques for measuring NE in vivo. Here, we developed a family of GPCR activation-based NE (GRAB
Indexed as
AnimalsAnimals, Genetically ModifiedElectric StimulationGreen Fluorescent ProteinsHypothalamusIntravital MicroscopyIn Vitro TechniquesLocus CoeruleusMesencephalonMiceMicroscopy, FluorescenceNorepinephrineOptogeneticsProtein EngineeringReceptors, Adrenergic, alpha-2Zebrafishenhanced green fluorescent proteinGreen Fluorescent ProteinsNorepinephrineReceptors, Adrenergic, alpha-2GPCRGRABNEneurotransmitternorepinephrinesensor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.