Evidence map›Paper›PMID 30922818›Full record

SynthesisThe Lancet. Infectious diseases2019

Effect of Plasmodium falciparum sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta-analysis.

Anna Maria van Eijk, David A Larsen, Kassoum Kayentao, Gibby Koshy, Douglas E C Slaughter, Cally Roper, Lucy C Okell, Meghna Desai, Julie Gutman, Carole Khairallah and 5 more

2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Lancet. Infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 92 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 6 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04634695 unknown statusnot on this mapstarted 2020, after this paper: background citation

Assessing the Prevalence and Impact of Dihydropteroate Synthase-431V Mutation on the Protective Efficacy of Intermittent Preventive Treatment During Pregnancy Using Sulphadoxine-pyrimethamine

Typeobservational_patient_registrySponsorObafemi Awolowo UniversityRan2020 to 2021Enrolled288ConditionsPregnancy Malaria
NCT05757167 phase4active not recruitingnot on this mapstarted 2023, after this paper: background citation

Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity

TypeinterventionalSponsorDuke UniversityRan2023 to 2026Enrolled2,174ConditionsMalaria,Falciparum, Malaria in Pregnancy, Malaria in Childbirth, PregnancyArmsMalaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL)
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 6 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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  13. Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Anna Maria van EijkDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
David A LarsenDepartment of Public Health, Food Studies and Nutrition, Syracuse University, Syracuse, NY, USA.
Kassoum KayentaoMalaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Dentistry, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.
Gibby KoshyDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Douglas E C SlaughterRollins School of Public Health, Emory University, Atlanta, GA, USA.
Cally RoperFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Lucy C OkellMRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK.
Meghna DesaiMalaria Branch, US Centers for Diseases Control and Prevention, Atlanta, GA, USA.
Julie GutmanMalaria Branch, US Centers for Diseases Control and Prevention, Atlanta, GA, USA.
Carole KhairallahDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Stephen J RogersonDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Carol Hopkins SibleyDepartment of Genome Sciences, University of Washington, Seattle, WA, USA; WorldWide Antimalarial Resistance Network, University of Oxford, Oxford, UK.
Steven R MeshnickDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Steve M TaylorDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; Division of Infectious Diseases and Duke Global Health Institute, Duke University Medical Center, Durham, NC, USA.
Feiko O Ter KuileDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: feiko.terkuile@lstmed.ac.uk.
Liverpool School of Tropical Medicine · GBUniversity of North Carolina at Chapel Hill · USEmory University · USImperial College London · GBLondon School of Hygiene & Tropical Medicine · GBSyracuse University · USUniversity of Bamako · MLUniversity of Melbourne · AUUniversity of Oxford · GB

Funding

Medical Research Council G1002387Medical Research Council MC_PC_MR/P006914/1Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

backgroundResistance of Plasmodium falciparum to sulfadoxine-pyrimethamine threatens the antimalarial effectiveness of intermittent preventive treatment during pregnancy (IPTp) in sub-Saharan Africa. We aimed to assess the associations between markers of sulfadoxine-pyrimethamine resistance in P falciparum and the effectiveness of sulfadoxine-pyrimethamine IPTp for malaria-associated outcomes.

methodsFor this systematic review and meta-analysis, we searched databases (from Jan 1, 1990 to March 1, 2018) for clinical studies (aggregated data) or surveys (individual participant data) that reported data on low birthweight (primary outcome) and malaria by sulfadoxine-pyrimethamine IPTp dose, and for studies that reported on molecular markers of sulfadoxine-pyrimethamine resistance. Studies that involved only HIV-infected women or combined interventions were excluded. We did a random-effects meta-analysis (clinical studies) or multivariate log-binomial regression (surveys) to obtain summarised dose-response data (relative risk reduction [RRR]) and multivariate meta-regression to explore the modifying effects of sulfadoxine-pyrimethamine resistance (as indicated by Ala437Gly, Lys540Glu, and Ala581Gly substitutions in the dhps gene). This study is registered with PROSPERO, number 42016035540.

findingsOf 1097 records screened, 57 studies were included in the aggregated-data meta-analysis (including 59 457 births). The RRR for low birthweight declined with increasing prevalence of dhps Lys540Glu (p

interpretationThe effectiveness of sulfadoxine-pyrimethamine IPTp is reduced in areas with high resistance to sulfadoxine-pyrimethamine among P falciparum parasites, but remains associated with reductions in low birthweight even in areas where dhps Lys540Glu prevalence exceeds 90% but where the sextuple-mutant parasite (harbouring the additional dhps Ala581Gly mutation) is uncommon. Therapeutic alternatives to sulfadoxine-pyrimethamine IPTp are needed in areas where the prevalence of the sextuple-mutant parasite exceeds 37%.

fundingUS Centers for Disease Control and Prevention, the Malaria in Pregnancy Consortium (funded through a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine), Worldwide Antimalarial Resistance Network, European and Developing Countries Clinical Trials Partnership.

Indexed as

Drug ResistanceAfricaAntimalarialsDrug CombinationsFemaleHumansInfant, Low Birth WeightInfant, NewbornMalaria, FalciparumMutationPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPyrimethamineSulfadoxineAntimalarialsDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxine

Identifiers

PMID30922818
OpenAlexW2922724938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.