Evidence map›Paper›PMID 30922812›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2019

A two-center analysis of hyperpolarized

Marcus J Couch, Robert Thomen, Nikhil Kanhere, Raymond Hu, Felix Ratjen, Jason Woods, Giles Santyr

Open access · greenAbstract read
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025
    Article
  6. Article
  7. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  8. Article
  9. Magnetic resonance in medicine · 2025
    Article
  10. Review
  11. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Article
  13. Article
  14. Journal of magnetic resonance imaging : JMRI · 2023
    Article
  15. Article
  16. Article
  17. HyperpolarizedAcademic radiology · 2022
    Article
  18. Review
  19. Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Marcus J CouchTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Robert ThomenSchool of Medicine, University of Missouri, Columbia, MO, USA.
Nikhil KanhereTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Raymond HuTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Felix RatjenTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Jason WoodsCenter for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Giles SantyrTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.. Electronic address: giles.santyr@sickkids.ca.
Hospital for Sick Children · CAUniversity of Toronto · CACincinnati Children's Hospital Medical Center · USUniversity of Missouri · US

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
NHLBI NIH HHS R01 HL131012NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

backgroundThe ventilation defect percent (VDP), measured from hyperpolarized (HP)

methodsThis retrospective analysis included 26 participants from two institutions (18 CF, 8 healthy, age range 10-17). Pulmonary function tests, N

resultsVDP measurements agreed for the two analysts with an intraclass correlation coefficient of 0.99. In the combined dataset, VDP measured by Analyst 1 was 5.96 ± 1.82% and 15.96 ± 6.76% for the healthy and CF groups, respectively (p = .0004). Analyst 2 showed similar differences between healthy and CF (p = .0003). VDP measured by either analyst was shown to correlate with FEV

conclusionHP

Indexed as

Cystic FibrosisLungXenon IsotopesAdolescentChildFemaleForced Expiratory VolumeHealth Status IndicatorsHumansMagnetic Resonance ImagingMalePulmonary VentilationRespiratory Function TestsRetrospective StudiesXenon-129Xenon IsotopesCystic fibrosisHyperpolarized (129)XeMagnetic resonance imagingVentilation defect percent

Identifiers

PMID30922812
PMCPMC7054852
OpenAlexW2923942876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.