Evidence map›Paper›PMID 30922713›Full record

Trial reportBrain stimulation

Significant improvement in treatment resistant auditory verbal hallucinations after 5 days of double-blind, randomized, sham controlled, fronto-temporal, transcranial direct current stimulation (tDCS): A replication/extension study.

Joshua T Kantrowitz, Pejman Sehatpour, Michael Avissar, Guillermo Horga, Anna Gwak, Mathew J Hoptman, Odeta Beggel, Ragy R Girgis, Blair Vail, Gail Silipo and 2 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01898299 (tDCS for Auditory Hallucinations in Schizophrenia), which is not on this map. Cited by 34 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01898299 nacompletednot on this map

tDCS for Auditory Hallucinations in Schizophrenia

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2013 to 2018Enrolled89ConditionsSchizophreniaArmstranscranial Direct Current Stimulation (tDCS), Sham tDCS
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joshua T KantrowitzSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA; Division of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA. Electronic address: jk3380@cumc.columbia.edu.
Pejman SehatpourSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA; Division of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Michael AvissarDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Guillermo HorgaDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Anna GwakDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Mathew J HoptmanSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA; Department of Psychiatry, NYU School of Medicine, New York, NY, 10016, USA.
Odeta BeggelSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA.
Ragy R GirgisDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Blair VailDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Gail SilipoSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA.
Marlene CarlsonDivision of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.
Daniel C JavittSchizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA; Division of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Training in Schizophrenia and Psychotic Disorders: From Animal Models to PatientsT32MH018870 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Guillermo Horga, Christoph Kellendonk · 1988 to 2026
$9.8M
EARLY CORTICAL PROCESSING IN SCHIZOPHRENIAR01MH049334 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI JAVITT, DANIEL C. · 1998 to 2022
$8.8M
Early Cortical Processing In SchizophreniaR37MH049334 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI JAVITT, DANIEL C. · 2003 to 2012
$4.2M
Functional connectivity and DTI in schizophreniaR21MH084031 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI HOPTMAN, MATTHEW J · 2009 to 2010
$428k
NCRR NIH HHS UL1 RR024156NIMH NIH HHS R01 MH049334NIMH NIH HHS R21 MH084031NIMH NIH HHS R37 MH049334NIMH NIH HHS T32 MH018870
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) is a potentially novel treatment for antipsychotic-resistant auditory verbal hallucinations (AVH) in schizophrenia. Nevertheless, results have been mixed across studies.

methods89 schizophrenia/schizoaffective subjects (active: 47; Sham: 42) were randomized to five days of twice-daily 20-min active tDCS vs. sham treatments across two recruitment sites. AVH severity was assessed using the Auditory Hallucination Rating Scale (AHRS) total score. To assess target engagement, MRI was obtained in a sub sample.

resultsWe observed a statistically significant, moderate effect-size change in AHRS total score across one-week and one-month favoring active treatment following covariation for baseline symptoms and antipsychotic dose (p = 0.036; d = 0.48). Greatest change was observed on the AHRS loudness item (p = 0.003; d = 0.69). In exploratory analyses, greatest effects on AHRS were observed in patients with lower cognitive symptoms (d = 0.61). In target engagement analysis, suprathreshold mean field-strength (>0.2 V/m) was seen within language-sensitive regions. However, off-target field-strength, which correlated significantly with less robust clinical response, was observed in anterior regions.

conclusionsThis is the largest study of tDCS for persistent AVH conducted to date. We replicate previous reports of significant therapeutic benefit, but only if medication dosage is considered, with patients receiving lowest medication dosage showing greatest effect. Response was also greatest in patients with lowest levels of cognitive symptoms. Overall, these findings support continued development of tDCS for persistent AVH, but also suggest that response may be influenced by specific patient and treatment characteristics. CLINICALTRIALS.GOV: NCT01898299.

Indexed as

AdultDouble-Blind MethodFemaleFrontal LobeHallucinationsHumansMagnetic Resonance ImagingMaleMiddle AgedSchizophreniaSchizophrenic PsychologyTemporal LobeTime FactorsTranscranial Direct Current StimulationTreatment OutcomeAuditory hallucinationsClinical trialSchizophreniaTarget engagementtDCS

Identifiers

PMID30922713
PMCPMC9896410

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.