ReviewTrends in genetics : TIG2019
Progress in Polygenic Composite Scores in Alzheimer's and Other Complex Diseases.
Review in Trends in genetics : TIG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Education as a Modifier of Genetic Influence on Cognitive Ability in Older Adults.Behavior genetics · 2025Article
- Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum.IBRO neuroscience reports · 2025Article
- Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Understanding Genetic Screening: Harnessing Health Information to Prevent Disease Risks.International journal of medical sciences · 2025Review
- Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation.BioData mining · 2024Article
- Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation.Research square · 2024Article
- Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes.Neurology. Genetics · 2024Article
- Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis.Brain : a journal of neurology · 2023Article
- The foundation and architecture of precision medicine in neurology and psychiatry.Trends in neurosciences · 2023Review
- Article
- The Allosteric Antagonist of the Sigma-2 Receptors-Elayta (CT1812) as a Therapeutic Candidate for Mild to Moderate Alzheimer's Disease: A Scoping Systematic Review.Life (Basel, Switzerland) · 2022Article
- Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease.Acta neuropathologica · 2022Article
- A Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment.Antioxidants (Basel, Switzerland) · 2022Article
- Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.European journal of nutrition · 2022Article
- Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden.Journal of Alzheimer's disease : JAD · 2022Article
- Alzheimer's Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes.Frontiers in aging neuroscience · 2022Article
- Polygenic coronary artery disease association with brain atrophy in the cognitively impaired.Brain communications · 2022Article
- Polygenic risk scores: the future of cancer risk prediction, screening, and precision prevention.Medical review (2021) · 2021Review
- Genetic prediction of complex traits with polygenic scores: a statistical review.Trends in genetics : TIG · 2021Review
- Functional co-activation of the default mode network in APOE ε4-carriers: A replication study.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Advances in high-throughput genotyping and next-generation sequencing (NGS) coupled with larger sample sizes brings the realization of precision medicine closer than ever. Polygenic approaches incorporating the aggregate influence of multiple genetic variants can contribute to a better understanding of the genetic architecture of many complex diseases and facilitate patient stratification. This review addresses polygenic concepts, methodological developments, hypotheses, and key issues in study design. Polygenic risk scores (PRSs) have been applied to many complex diseases and here we focus on Alzheimer's disease (AD) as a primary exemplar. This review was designed to serve as a starting point for investigators wishing to use PRSs in their research and those interested in enhancing clinical study designs through enrichment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.