Evidence map›Paper›PMID 30922358›Full record

ArticleTrials2019

Use of a Geographic Information System to create treatment groups for group-randomized community trials: The Minnesota Heart Health Program.

Brittany Krzyzanowski, Steven M Manson, Milton Mickey Eder, Len Kne, Niki Oldenburg, Kevin Peterson, Alan T Hirsch, Russell V Luepker, Sue Duval

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02607917 (Testing a Community Intervention to Increase Aspirin Use for Primary Prevention of Cardiovascular Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02607917 nacompletednot on this map

Testing a Community Intervention to Increase Aspirin Use for Primary Prevention of Cardiovascular Disease

TypeinterventionalSponsorUniversity of MinnesotaRan2015 to 2020Enrolled10,800ConditionsMyocardial Infarction, StrokeArmsMass Media plus clinic intervention., Media
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brittany KrzyzanowskiDepartment of Geography, Environment & Society, University of Minnesota, Minneapolis, MN, USA.
Steven M MansonDepartment of Geography, Environment & Society, University of Minnesota, Minneapolis, MN, USA.
Milton Mickey EderDepartment of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN,, USA.
Len KneU-Spatial, Office of Vice President for Research, University of Minnesota, Minneapolis, MN, USA.
Niki OldenburgCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.
Kevin PetersonDepartment of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN,, USA.
Alan T HirschCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.
Russell V LuepkerCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA.
Sue DuvalCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, 420 Delaware Street SE, MMC 508, Minneapolis, MN, 55455, USA. sueduval@umn.edu.ORCID http://orcid.org/0000-0003-1025-8665

Funding

Minnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3M
Testing a Community Intervention to Increase Aspirin Use for Primary Prevention of Cardiovascular DiseaseR01HL126041 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUEPKER, RUSSELL V · 2015 to 2019
$3.5M
NHLBI NIH HHS R01 HL126041NHLBI NIH HHS R01HL126041
6 · The paper itself

Abstract

backgroundGroup-randomized trials of communities often rely on the convenience of pre-existing administrative divisions, such as school district boundaries or census entities, to divide the study area into intervention and control sites. However, these boundaries may include substantial heterogeneity between regions, introducing unmeasured confounding variables. This challenge can be addressed by the creation of exchangeable intervention and control territories that are equally weighted by pertinent socio-demographic characteristics. The present study used territory design software as a novel approach to partitioning study areas for The Minnesota Heart Health Program's "Ask about Aspirin" Initiative.

methodsTwenty-four territories were created to be similar in terms of age, sex, and educational attainment, as factors known to modify aspirin use. To promote ease of intervention administration, the shape and spread of the territories were controlled. Means of the variables used in balancing the territories were assessed as well as other factors that were not used in the balancing process.

resultsThe analysis demonstrated that demographic characteristics did not differ significantly between the intervention and control territories created by the territory design software.

conclusionsThe creation of exchangeable territories diminishes geographically based impact on outcomes following community interventions in group-randomized trials. The method used to identify comparable geographical units may be applied to a wide range of population-based health intervention trials.

trial registrationNational Institutes of Health (Clinical Trials.gov), Identifier: NCT02607917 . Registered on 16 November 2015.

Indexed as

Geographic Information SystemsPatient SelectionAgedAspirinCardiovascular AgentsCommunity Health ServicesCross-Over StudiesFemaleHumansMaleMiddle AgedMinnesotaMulticenter Studies as TopicMyocardial InfarctionPrimary PreventionRandomized Controlled Trials as TopicAspirinCardiovascular AgentsCommunity intervention methodsGeographic information system (GIS)Group-randomized trialsPublic health interventions

Identifiers

PMID30922358
PMCPMC6438016

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.