ArticleRadiation oncology (London, England)2019
Proposed revision of the 8th edition AJCC clinical staging system for esophageal squamous cell cancer treated with definitive chemo-IMRT based on CT imaging.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- CT-based radiomics for predicting lymph node metastasis in esophageal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Sodium glycididazole combined with definitive chemoradiotherapy for patients with esophageal squamous cell carcinoma: A multicenter randomized clinical trial.Precision radiation oncology · 2026Article
- Dual-layer spectral detector computed tomography multiparameter machine learning model for prediction of lymph node metastases in esophageal squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Predictive significance of thoracic skeletal muscle nutritional status for radiotherapy survival in elderly patients with esophageal squamous cell carcinoma.Oncology letters · 2026Article
- Analyses on patterns of lymph node metastasis and its impact on prognosis in thoracic esophageal squamous cell carcinoma treated with neoadjuvant immunochemotherapy versus chemotherapy alone: a single-center, retrospective cohort study.Frontiers in immunology · 2026Article
- Prognostic impact of low BMI on outcomes following definitive radiotherapy for esophageal squamous cell carcinoma.Frontiers in nutrition · 2026Article
- Validation and refinement of the 8th edition of the AJCC staging system for esophageal squamous cell carcinoma treated with definitive IMRT or chemo-IMRT: a Chinese multi-institutional retrospective study.Radiation oncology (London, England) · 2025Article
- Optimal Time-to-Surgery Recommendations Based on Primary Tumor Volume Regression for Patients with Resectable Esophageal Cancer after Neoadjuvant Chemoradiotherapy: A Retrospective Study.Annals of surgical oncology · 2024Article
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- Development of a prognostic nomogram and risk stratification system for upper thoracic esophageal squamous cell carcinoma.Frontiers in oncology · 2023Article
- Influence of age as a continuous variable on survival outcomes and treatment options in patients with upper thoracic esophageal carcinoma.Journal of Cancer · 2023Article
- The novel pretreatment immune prognostic index discriminates survival outcomes in locally advanced non-operative esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: a 6-year retrospective study.Translational oncology · 2022Article
- Esophageal wall thickness on CT scans: can it predict the T stage of primary thoracic esophageal squamous cell carcinoma?Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Prognostic values of the gross volume of metastatic lymph nodes in patients with esophageal squamous cell carcinoma treated with definitive concurrent chemoradiotherapy.Frontiers in oncology · 2022Article
- Radiomics Analysis of Lymph Nodes with Esophageal Squamous Cell Carcinoma Based on Deep Learning.Journal of oncology · 2022Article
- Primary gross tumor volume is prognostic and suggests treatment in upper esophageal cancer.BMC cancer · 2021Article
- Tumor size measured by multidetector CT in resectable colon cancer: correlation with regional lymph node metastasis and N stage.World journal of surgical oncology · 2021Article
- Contrast-Enhanced CT-Based Radiomics Analysis in Predicting Lymphovascular Invasion in Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2021Article
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
Abstract
purposeTo validate and propose revision of the 8th edition American Joint Committee on Cancer (AJCC) clinical staging system for esophageal squamous cell cancer (ESCC) patients treated with definitive intensity-modulated radiation therapy combined with concurrent chemotherapy (Chemo-IMRT) based on computed tomography (CT) imaging.
methodsThe clinical data of patients with ESCC treated with Chemo-IMRT were collected and retrospectively reviewed. All CT images were independently reevaluated and restaged according to the 8th edition AJCC staging system. The overall survival (OS) rates were analyzed statistically. ROC curves of the various parameters of the primary tumor and metastatic lymph nodes were generated in order to identify the cutoff values correlated to patient survival using the area under curve.
resultsThe gross tumor volume of the primary tumor (GTV-prT) and the clinical N stage (cN) were independent factors that influenced OS. The 5-year OS rate of patients with GTV-prT ≤28 cm
conclusionThe SLNM should be dealt with as a regional rather than a distant disease in patients with ESCC when treated with CRT. The proposed nonsurgical staging system based on the GTV-prT and N appears to be a simple and accurate prognosis predictor for patients with ESCC who have undergone definitive Chemo-IMRT.
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