Observational studyMalaria journal2019
Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands.
Observational study in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Population genomics of Plasmodium malariae from 4 African countries.JCI insight · 2026Article
- Asymptomatic/submicroscopicParasite epidemiology and control · 2025Article
- High-throughput genotyping of Plasmodium vivax in the Peruvian Amazon via molecular inversion probes.Nature communications · 2024Article
- Application of 23 Novel Serological Markers for Identifying Recent Exposure toFrontiers in microbiology · 2021Article
- Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka.Malaria journal · 2020Article
- Development and validation of serological markers for detecting recent Plasmodium vivax infection.Nature medicine · 2020Observational
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Authors and funding
13 authors.
Funding
Abstract
backgroundFollowing the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malaria elimination in this country. Since children have higher risk of contracting malaria, this study investigated the dynamics of Plasmodium spp. infections among children including the associated risk factors of residual P. vivax burden.
methodsAn observational cohort study was conducted among 860 children aged 0.5-12 years in Ngella (Central Islands Province, SI). Children were monitored by active and passive surveillances for Plasmodium spp. infections and illness. Parasites were detected by quantitative real-time PCR (qPCR) and genotyped. Comprehensive statistical analyses of P. vivax infection prevalence, molecular force of blood stage infection (
resultsPlasmodium vivax infections were common (overall prevalence: 11.9%), whereas Plasmodium falciparum infections were rare (0.3%) but persistent. Although children acquire an average of 1.1 genetically distinct P. vivax blood-stage infections per year, there was significant geographic heterogeneity in the risks of P. vivax infections across Ngella (prevalence: 1.2-47.4%, p < 0.01;
conclusionResidual malaria transmission in Ngella exhibits strong heterogeneity and is characterized by a high proportion of submicroscopic and asymptomatic P. vivax infections, alongside sporadic P. falciparum infections. Implementing an appropriate primaquine treatment policy to prevent P. vivax relapses and specific targeting of control interventions to high risk areas will be required to accelerate ongoing control and elimination activities.
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