ArticleBMC nephrology2019
Increased cancer risk in patients undergoing dialysis: a population-based cohort study in North-Eastern Italy.
Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Incidence of major urological cancers in patients on dialysis: a systematic review and meta-analysis.World journal of surgical oncology · 2025Pooled it
- Cancer Risk in Haemodialysis Patients Compared With That in the General Population: A Multicenter Questionnaire-Based Study in Okinawa, Japan.Nephrology (Carlton, Vic.) · 2026Observational
- Critical considerations in the administration of antineoplastic therapy for patients with malignant solid tumors undergoing hemodialysis.Frontiers in oncology · 2026Review
- Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies.Discover oncology · 2025Article
- Management of cytotoxic chemotherapy in patients undergoing dialysis: a still unresolved issue of onconephrology.Journal of nephrology · 2025Review
- Uncovering the Risk: Incidence of Upper Tract Urothelial Carcinoma Following Renal Transplantation in the Netherlands.European urology open science · 2025Article
- Cancer diagnosis and prognosis after initiation of hemodialysis: multicenter Japan CANcer and DialYsis (J-CANDY) study.Clinical kidney journal · 2025Article
- Review
- Systemic oncological therapy in breast cancer patients on dialysis.World journal of clinical oncology · 2024Review
- Cancer before and after the start of hemodialysis and association with mortality - an Eastern-European multicenter study.Renal failure · 2023Article
- Article
- Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis.Open life sciences · 2023Article
- Postoperative outcomes of cancer surgery in patients with and without kidney failure with dialysis therapy: a matched-pair cohort study.Clinical kidney journal · 2022Article
- The Effect of Statins in Cancer Risk Reduction in Patients on Dialysis: A Population-Based Case-Control Study.Journal of clinical medicine · 2021Article
- "Together We Stand": A Pilot Study Exploring the Feasibility, Acceptability, and Preliminary Effects of a Family-Based Psychoeducational Intervention for Patients on Hemodialysis and Their Family Caregivers.Healthcare (Basel, Switzerland) · 2021Article
- Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges.World journal of gastroenterology · 2021Review
- Immunoglobulin A Vasculitis in a Patient on Hemodialysis and With a Metastatic Liver Lesion.Cureus · 2021Article
- Treatment options for localised renal cell carcinoma of the transplanted kidney.World journal of transplantation · 2020Review
- Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Review
- Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo malignancies (DNMs) among dialysis patients in the Friuli Venezia Giulia region, north-eastern Italy.
methodsA population-based cohort study among 3407 dialysis patients was conducted through a record linkage between local healthcare databases and the cancer registry (1998-2013). Person-years (PYs) were calculated from 30 days after the date of first dialysis to the date of DNM diagnosis, kidney transplant, death, last follow-up or December 31, 2013, whichever came first. The risk of DNM, as compared to the general population, was estimated using standardized incidence ratios (SIRs) and 95% confidence intervals (CIs).
resultsDuring 10,798 PYs, 357 DNMs were diagnosed in 330 dialysis patients. A higher than expected risk of 1.3-fold was found for all DNMs combined (95% CI: 1.15-1.43). The risk was particularly high in younger dialysis patients (SIR = 1.88, 95% CI: 1.42-2.45 for age 40-59 years), and it decreased with age. Moreover, significantly increased DNM risks emerged during the first 3 years since dialysis initiation, especially within the first year (SIR = 8.52, 95% CI: 6.89-10.41). Elevated excess risks were observed for kidney (SIR = 3.18; 95% CI: 2.06-4.69), skin non-melanoma (SIR = 1.81, 95% CI: 1.46-2.22), oral cavity (SIR = 2.42, 95% CI: 1.36-4.00), and Kaposi's sarcoma (SIR = 10.29, 95% CI: 1.25-37.16).
conclusionsThe elevated risk for DNM herein documented suggest the need to implement a targeted approach to cancer prevention and control in dialysis patients.
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