Evidence map›Paper›PMID 30922182›Full record

ArticlePrion2019

The insomnia phenotype in genetic Creutzfeldt-Jakob disease based on the E200K mutation.

Eva Feketeova, Dominika Jarcuskova, Alzbeta Janakova, Marianna Vitkova, Jozef Dragasek, Zuzana Gdovinova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eva Feketeovaa Department of Neurology , P.J. Safarik University , Kosice , Slovakia.ORCID 0000-0002-7746-3797
Dominika Jarcuskovaa Department of Neurology , P.J. Safarik University , Kosice , Slovakia.
Alzbeta Janakovad Department of Prion Diseases , Slovak Medical University , Bratislava , Slovakia.
Marianna Vitkovaa Department of Neurology , P.J. Safarik University , Kosice , Slovakia.
Jozef Dragasekc 1st Department of Psychiatry , University Hospital of L. Pasteur , Kosice , Slovakia.
Zuzana Gdovinovaa Department of Neurology , P.J. Safarik University , Kosice , Slovakia.
University of Pavol Jozef Šafárik · SKSlovak Medical University · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the presented study was to reveal the frequency of insomnia spells in E200K genetic Creutzfeldt-Jakob disease (gCJD) patients. Clinical records of 22 subjects diagnosed with E200K gCJD were retrospectively reviewed. The patients w/wo insomnia (n = 4, 18%/n = 18, 82%) did not differ in age, sex and the duration of the symptomatic phase. Analysis of the clinical features in the groups yielded differences in the clinical signs in the early phase of the disorder, proportion of homozygotes (Met/Met) at codon 129, MRI changes in the thalamus and the typical EEG abnormality. The study suggests that apart from traditional clinical features, the insomnia is not a rare early symptom in phenotype of E200K gCJD based on early thalamic involvement.

Indexed as

Point MutationAgedCreutzfeldt-Jakob SyndromeFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPhenotypePrion ProteinsRetrospective StudiesSleep Initiation and Maintenance DisordersPrion ProteinsPRNP protein, humanE200Kgenetic Creutzfeldt–Jakob diseaseInsomniapolysomnographyprion diseases

Identifiers

PMID30922182
PMCPMC7000144
OpenAlexW2933556148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.