Evidence map›Paper›PMID 30922081›Full record

ReviewCephalalgia : an international journal of headache2019

Current understanding of cortical structure and function in migraine.

Else A Tolner, Shih-Pin Chen, Katharina Eikermann-Haerter

Open access · bronzeAbstract readReview
In one paragraph

Review in Cephalalgia : an international journal of headache, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  9. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
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  20. Cognitive assessment during the phases of a spontaneous migraine: a prospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Else A TolnerDepartments of Neurology and Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Shih-Pin ChenInsitute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei.ORCID https://orcid.org/0000-0003-3492-9902
Katharina Eikermann-HaerterDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USLeiden University Medical Center · NLNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review and discuss the literature on the role of cortical structure and function in migraine. DISCUSSION: Structural and functional findings suggest that changes in cortical morphology and function contribute to migraine susceptibility by modulating dynamic interactions across cortical and subcortical networks. The involvement of the cortex in migraine is well established for the aura phase with the underlying phenomenon of cortical spreading depolarization, while increasing evidence suggests an important role for the cortex in perception of head pain and associated sensations. As part of trigeminovascular pain and sensory processing networks, cortical dysfunction is likely to also affect initiation of attacks.

conclusionMorphological and functional changes identified across cortical regions are likely to contribute to initiation, cyclic recurrence and chronification of migraine. Future studies are needed to address underlying mechanisms, including interactions between cortical and subcortical regions and effects of internal (e.g. genetics, gender) and external (e.g. sensory inputs, stress) modifying factors, as well as possible clinical and therapeutic implications.

Indexed as

AnimalsCerebral CortexCerebrovascular CirculationCortical Spreading DepressionDisease Models, AnimalElectroencephalographyEvoked Potentials, VisualHumansIon ChannelsMeningesMiceMice, Mutant StrainsMigraine DisordersMigraine with AuraModels, NeurologicalNerve NetIon Channelscortexcortical spreading depolarizationfunctional connectivityMigraineneuroimagingneurophysiology

Identifiers

PMID30922081
PMCPMC6859601
OpenAlexW2935467049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.