ArticleDevelopmental cognitive neuroscience2019
Early-childhood social reticence predicts SCR-BOLD coupling during fear extinction recall in preadolescent youth.
Article in Developmental cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of social anxiety on threat acquisition and extinction: a systematic review and meta-analysis.PeerJ · 2024Pooled it
- Augmenting extinction with counterconditioning strengthens and sustains neural safety representations in PTSD.Translational psychiatry · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- A Multi-Component Model of Emotion Response Convergence: Implications for the Development of Psychopathology.Emotion review : journal of the International Society for Research on Emotion · 2025Article
- A preliminary study of threat-anticipatory responding in Latina youth: associations with age, anxiety, and cortical thickness.Social cognitive and affective neuroscience · 2024Article
- Development of Neural Mechanisms Underlying Threat Processing: Associations With Childhood Social Reticence and Adolescent Anxiety.Biological psychiatry global open science · 2023Article
- Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents' Neural Responses to Cognitive Conflict.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Anxiety symptoms and puberty interactively predict lower cingulum microstructure in preadolescent Latina girls.Scientific reports · 2022Article
- Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans.eLife · 2022Article
- Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability.Journal of affective disorders · 2021Article
- Social relevance modulates multivariate neural representations of threat generalization in children and adults.Developmental psychobiology · 2021Article
- Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.Behavioural brain research · 2021Article
- Puberty drives fear learning during adolescence.Developmental science · 2021Article
- Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure.Biological psychiatry · 2020Article
- Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.The American journal of psychiatry · 2020Article
- Divergence in cortical representations of threat generalization in affective versus perceptual circuitry in childhood: Relations with anxiety.Neuropsychologia · 2020Article
- Article
- Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth.Frontiers in endocrinology · 2020Article
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11 authors.
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Abstract
Social Reticence (SR) is a temperament construct identified in early childhood that is expressed as shy, anxiously avoidant behavior and, particularly when stable, robustly associated with risk for anxiety disorders. Threat circuit function may develop differently for children high on SR than low on SR. We compared brain function and behavior during extinction recall in a sample of 11-to-15-year-old children characterized in early childhood on a continuum of SR. Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. Whereas self-report and psychophysiological measures of differential conditioning, extinction, and extinction recall were largely similar across participants, SR-related differences in brain function emerged during extinction recall. Specifically, childhood SR was associated with a distinct pattern of hemodynamic-autonomic covariation in the brain when recalling extinguished threat and safety cues. SR and attention focus impacted associations between trial-by-trial variation in autonomic responding and in brain activation. These interactions occurred in three main brain areas: the anterior insular cortex (AIC), the anterior subdivision of the medial cingulate cortex (aMCC), and the dorsolateral prefrontal cortex (dlPFC). This pattern of SCR-BOLD coupling may reflect selective difficulty tracking safety in a temperamentally at-risk population.
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