Evidence map›Paper›PMID 30921379›Full record

Trial reportPloS one2019

Medication-related quality of life among Ethiopian elderly patients with polypharmacy: A cross-sectional study in an Ethiopia university hospital.

Henok Getachew Tegegn, Daniel Asfaw Erku, Girum Sebsibe, Biruktawit Gizaw, Dawit Seifu, Masho Tigabe, Sewunet Admasu Belachew, Asnakew Achaw Ayele

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Polypharmacy and trajectories of health-related quality of life in older adults: an Australian cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Henok Getachew TegegnDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.ORCID 0000-0003-0644-0958
Daniel Asfaw ErkuDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Girum SebsibeDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Biruktawit GizawDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Dawit SeifuDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Masho TigabeDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Sewunet Admasu BelachewDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
Asnakew Achaw AyeleDepartment of Clinical Pharmacy, University of Gondar, Gondar, Amhara, Ethiopia.
University of Gondar · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polypharmacy among older patients has been associated with a decline in their quality of life. We aimed to assess the medication-related quality of life (MRQOL) among older patients with polypharmacy at Gondar University Hospital, Gondar, Ethiopia. A prospective cross-sectional study was carried out among 150 elder patients who had visited the internal medicine ward and ambulatory ward of Gondar referral hospital from March 25 to May 15, 2017, using a validated scale, Medication-Related Quality of Life Scale version 1.0 (MRQoLS-v1.0). A total of 150 older patients with polypharmacy participated in the study with a mean age of 70.06±5.12, andtwo-thirds of the participants (67.3%) were female. The overall prevalence of poor quality of life due to polypharmacy in the current study was found to be three fourth (75.3%) of the participants. Regarding the severity of impairment in MRQoL, Univariate analysis revealed that frequency of hospital visits (COR = 1.34, 95% CI, 1.02-1.77) and medication number (COR = 1.94, 95% CI, 1.33, 2.8) had a statistically significant positive association with the likelihood of having a severe impairment.The multivariate analysis also showed that one unit increase in the number of hospital visits (AOR = 1.45, 95% CI, 1.040-2.024) and medications greater than 5 (AOR = 1.91, 95% CI, 1.29, 2.84) increases 1.45 and 1.91 times the likely hood of posing severe impairment of MRQoL, respectively. As far as poor MRQoL quality of life is concerned, multivariate analysis did not show any significant association between the poor MRQoL;and Sociodemographic and clinical data of patients. The poor QoL associated with medication was very high in this study. Deprescribing should be sought by the health care providers to optimize drug therapy and minimize the polypharmacy related poor quality of life.

Indexed as

Hospitals, UniversityPolypharmacyQuality of LifeAgedAged, 80 and overCross-Sectional StudiesDeprescriptionsEthiopiaFemaleHumansMalePrevalenceProspective Studies

Identifiers

PMID30921379
PMCPMC6438590
OpenAlexW2935654744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.