Evidence map›Paper›PMID 30921207›Full record

Observational studyMedicine2019

Hidden blood loss during perioperative period and the influential factors after surgery of thoracolumbar burst fracture: A retrospective case series.

Mengchen Yin, Guanghui Chen, Jian Yang, Zhengyi Tong, Jinhai Xu, Quan Huang, Junming Ma, Wen Mo

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. The influence of topical use of tranexamic acid in reducing blood loss on early operation for thoracolumbar burst fracture: a randomized double-blinded controlled study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengchen YinDepartment of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.
Guanghui ChenDepartment of Orthopedics, Peking University Third Hospital, Beijing.
Jian YangDepartment of Bone Tumor Surgery, Changzheng Hospital, Navy Medical University, Shanghai, China.
Zhengyi TongDepartment of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.
Jinhai XuDepartment of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.
Quan HuangDepartment of Bone Tumor Surgery, Changzheng Hospital, Navy Medical University, Shanghai, China.
Junming MaDepartment of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.
Wen MoDepartment of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical therapy is vital for thoracolumbar burst fracture in restoring vertebral height, correcting kyphosis, decompressing nervous, and maintaining stability. Patients have unexpectedly lower hemoglobin levels postoperatively, which is remarkably inconsistent with the measured blood loss. However, hidden blood loss (HBL) is often neglected.To investigate HBL during perioperative period and determine its influential factors after surgery.A total of 68 patients who underwent surgery in our institution between January 2015 and January 2017 were included in the study. The demographic information, including the patients' age, gender, weight, height, duration of symptoms, surgery approach, time of operation, volume of drainage, classification of fracture, percentage of vertebral height loss and restoration, was collected. HBL was calculated according to the Gross formula. Influential factors were further analyzed using multivariate linear regression analysis.The mean HBL was 303.5 (range 18.4-803.5) mL, accounting for 67.5% of total blood loss. It indicated that the amount of HBL was much higher than we expected. Multiple and stepwise regression analysis revealed that blood loss, preoperative activated partial prothrombin time (APPT), percentage of anterior and medium vertebral height restoration were positively correlated with HBL. The association between HBL and the influential factors was analyzed based on the regression model equation: HBL = [1 + e [216.737 + 0.627*blood loss + 10.817*APTT + 207.549*anterior height restoration + 20.002*medium height restoration]]-1.HBL during perioperative period accounted for a substantial portion of the total blood loss and was much larger than what we thought. The blood loss, preoperative APPT, percentage of anterior and medium vertebral height restoration were positively correlated with HBL. Therefore, more attention needs to be paid to HBL to ensure patients' safety.

Indexed as

AdultAgedAged, 80 and overAge FactorsBlood Loss, SurgicalBody Weights and MeasuresFemaleHemoglobinsHumansKyphosisLumbar VertebraeMaleMiddle AgedPartial Thromboplastin TimePerioperative PeriodRegression AnalysisHemoglobins

Identifiers

PMID30921207
PMCPMC6455821

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.