SynthesisThe International journal of eating disorders2019
Increased lipid and lipoprotein concentrations in anorexia nervosa: A systematic review and meta-analysis.
Synthesis in The International journal of eating disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Integrative GWAS identifies novel loci and genetic links between psychiatric and metabolic factors in anorexia nervosa.Molecular psychiatry · 2026Pooled it
- Body composition in anorexia nervosa: Meta-analysis and meta-regression of cross-sectional and longitudinal studies.The International journal of eating disorders · 2019Pooled it
- Clinical Risk Factors Differ by Sex for Kidney Complications but Not Retinopathy in Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Cohort.Diabetes care · 2026Article
- Relationships between body composition, lipid metabolism, and platelet fatty acid profiles in women with anorexia nervosa: a cross-sectional study.Scientific reports · 2026Article
- A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions.Molecular psychiatry · 2026Article
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Coagulation activation in anorexia nervosa: increased tissue factor and prothrombin fragment 1+2.Research and practice in thrombosis and haemostasis · 2026Article
- Exploring the Genetic Overlap Between Metabolic Traits and Anorexia Nervosa.Biological psychiatry global open science · 2026Article
- Psychopathology and Other Mental Health Challenges in Siblings of Patients with Child- or Adolescent-Onset Anorexia Nervosa: A Systematic Review with a Sex/Gender Perspective.Journal of clinical medicine · 2026Review
- Increased risk of thromboembolism in patients with anorexia nervosa: a Danish nationwide registry-based study.BMC medicine · 2025Observational
- Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer.European journal of heart failure · 2025Article
- Eating disorders, nutrient intake, and cardiometabolic risks: a cross-sectional study in Turkish adults.BMC public health · 2025Article
- The Role of Age at Onset on the Clinical Course and Biochemical Parameters of Anorexia Nervosa.Journal of personalized medicine · 2025Article
- Evaluation of the Sphingolipidomic Profile in Women with Anorexia Nervosa: Relationships with Parameters Related to Body Composition, Cardiovascular Function, Glucometabolic Homeostasis, and Lipoprotein Metabolism.Journal of clinical medicine · 2025Article
- Dyslipidemia in Anorexia Nervosa Is Associated with Decreased Plasma Tauroursodeoxycholic Acid and a Specific Fatty Acid Pattern.Nutrients · 2025Article
- Case Report: From disordered eating to an eating disorder-a case study of an orienteering athlete with anorexia nervosa and the shortcomings of the multidisciplinary approach.Frontiers in psychology · 2025Article
- Association between the risk of relative energy deficiency in sport and cholesterol levels in Finnish endurance athletes.BMJ open sport & exercise medicine · 2025Article
- A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment.Journal of eating disorders · 2024Article
- Bioelectrical Impedance Vector Analysis, Nutritional UltrasoundNutrients · 2024Article
- Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders.Fukushima journal of medical science · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveAlterations in blood lipid concentrations in anorexia nervosa (AN) have been reported; however, the extent, mechanism, and normalization with weight restoration remain unknown. We conducted a systematic review and a meta-analysis to evaluate changes in lipid concentrations in acutely-ill AN patients compared with healthy controls (HC) and to examine the effect of partial weight restoration.
methodA systematic literature review and meta-analysis (PROSPERO: CRD42017078014) were conducted for original peer-reviewed articles.
resultsForty-eight studies were eligible for review; 33 for meta-analyses calculating mean differences (MD). Total cholesterol (MD = 22.7 mg/dL, 95% CI = 12.5, 33.0), high-density lipoprotein (HDL; MD = 3.4 mg/dL, CI = 0.3, 7.0), low-density lipoprotein (LDL; MD = 12.2 mg/dL, CI = 4.4, 20.1), triglycerides (TG; MD = 8.1 mg/dL, CI = 1.7, 14.5), and apolipoprotein B (Apo B; MD = 11.8 mg/dL, CI = 2.3, 21.2) were significantly higher in acutely-ill AN than HC. Partially weight-restored AN patients had higher total cholesterol (MD = 14.8 mg/dL, CI = 2.1, 27.5) and LDL (MD = 16.1 mg/dL, CI = 2.3, 30.0). Pre- versus post-weight restoration differences in lipid concentrations did not differ significantly. DISCUSSION: We report aggregate evidence for elevated lipid concentrations in acutely-ill AN patients compared with HC, some of which persist after partial weight restoration. This could signal an underlying adaptation or dysregulation not fully reversed by weight restoration. Although concentrations differed between AN and HC, most lipid concentrations remained within the reference range and meta-analyses were limited by the number of available studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.