Evidence map›Paper›PMID 30920514›Full record

ArticleGels (Basel, Switzerland)2017

Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications.

Nicole Zoratto, Francesca Romana Palmieri, Claudia Cencetti, Elita Montanari, Chiara Di Meo, Maria Letizia Manca, Maria Manconi, Pietro Matricardi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicole ZorattoDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. nicole.zoratto@uniroma1.it.
Francesca Romana PalmieriDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. palmieri.1247758@studenti.uniroma1.it.
Claudia CencettiDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. claudia.cencetti@gmail.com.
Elita MontanariDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. elita.montanari@uniroma1.it.
Chiara Di MeoDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. chiara.dimeo@uniroma1.it.
Maria Letizia MancaDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy. mlmanca@unica.it.
Maria ManconiDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy. manconi@unica.it.
Pietro MatricardiDepartment of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. pietro.matricardi@uniroma1.it.ORCID 0000-0003-2086-911X
Sapienza University of Rome · ITUniversity of Cagliari · IT

Funding

Sapienza Università di Roma C26A15MH7C
6 · The paper itself

Abstract

Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug depot applications.

Indexed as

depotdrug deliverygellan–cholesterolhydrogelP90G liposomes

Identifiers

PMID30920514
PMCPMC6318693
OpenAlexW2614084826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.