Evidence map›Paper›PMID 30920354›Full record

ReviewPhysiological reviews2019

The Sleep-Immune Crosstalk in Health and Disease.

Luciana Besedovsky, Tanja Lange, Monika Haack

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06341374 (Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients. A Cohort Study), which is not on this map. Cited by 754 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
754citing papers in PubMed, 6 pooled it
106.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06341374 unknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients. A Cohort Study

Typeobservational_patient_registrySponsorParc Taulí Hospital UniversitariRan2023 to 2024Enrolled50ConditionsApnea, Obstructive Sleep, SARS CoV 2 InfectionArmsInfluvac Tetra
3 · Its place in the literature

Who cites it

754 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,370 citations in OpenAlex.

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694 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Luciana BesedovskyInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen , Tübingen , Germany ; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts ; and Department of Rheumatology and Clinical Immunology, University of Lübeck , Lübeck , Germany.
Tanja LangeInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen , Tübingen , Germany ; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts ; and Department of Rheumatology and Clinical Immunology, University of Lübeck , Lübeck , Germany.ORCID 0000-0001-8309-2112
Monika HaackInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen , Tübingen , Germany ; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts ; and Department of Rheumatology and Clinical Immunology, University of Lübeck , Lübeck , Germany.
Beth Israel Deaconess Medical Center · US

Funding

Patterns of Sleep Restriction and Recovery: The Inflammatory Resolution PathwaysR01HL136310 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAACK, MONIKA · 2018 to 2022
$4.1M
Pain Sensitization and Habituation in a Model of Experimentally-Induced Insomnia SymptomsR01NS091177 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAACK, MONIKA · 2015 to 2018
$2.7M
NHLBI NIH HHS R01 HL136310NINDS NIH HHS R01 NS091177
6 · The paper itself

Abstract

Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body's defense system. Stimulation of the immune system by microbial challenges triggers an inflammatory response, which, depending on its magnitude and time course, can induce an increase in sleep duration and intensity, but also a disruption of sleep. Enhancement of sleep during an infection is assumed to feedback to the immune system to promote host defense. Indeed, sleep affects various immune parameters, is associated with a reduced infection risk, and can improve infection outcome and vaccination responses. The induction of a hormonal constellation that supports immune functions is one likely mechanism underlying the immune-supporting effects of sleep. In the absence of an infectious challenge, sleep appears to promote inflammatory homeostasis through effects on several inflammatory mediators, such as cytokines. This notion is supported by findings that prolonged sleep deficiency (e.g., short sleep duration, sleep disturbance) can lead to chronic, systemic low-grade inflammation and is associated with various diseases that have an inflammatory component, like diabetes, atherosclerosis, and neurodegeneration. Here, we review available data on this regulatory sleep-immune crosstalk, point out methodological challenges, and suggest questions open for future research.

Indexed as

AnimalsHomeostasisHumansImmune SystemImmunityImmunity, InnateSleepSleep Deprivation

Identifiers

PMID30920354
PMCPMC6689741
OpenAlexW2927147597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.