ArticleJournal of biomedical materials research. Part A2019
Multimodal porogen platforms for calcium phosphate cement degradation.
Article in Journal of biomedical materials research. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
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- Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability.Biomedicines · 2021Review
- Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment.EFORT open reviews · 2021Review
- Gluing Living Bone Using a Biomimetic Bioadhesive: From Initial Cut to Final Healing.Frontiers in bioengineering and biotechnology · 2021Article
- Advances in biomaterials for skeletal muscle engineering and obstacles still to overcome.Materials today. Bio · 2020Review
- Three-Dimensional Extrusion Printing of Porous Scaffolds Using Storable Ceramic Inks.Tissue engineering. Part C, Methods · 2020Article
- Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration.Biomedical materials (Bristol, England) · 2020Article
- Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release.Frontiers in bioengineering and biotechnology · 2020Article
- Multimodal porogen platforms for calcium phosphate cement degradation.Journal of biomedical materials research. Part A · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Calcium phosphate cements (CPCs) represent excellent bone substitute materials due to their biocompatibility and injectability. However, their poor degradability and lack of macroporosity limits bone regeneration. The addition of poly(d,l-lactic-co-glycolic acid) (PLGA) particles improves macroporosity and therefore late stage material degradation. CPC degradation and hence, bone formation at an early stage remains challenging, due to the delayed onset of PLGA degradation (i.e., after 2-3 weeks). Consequently, we here explored multimodal porogen platforms based on sucrose porogens (for early pore formation) and PLGA porogens (for late pore formation) to enhance CPC degradation and analyzed mechanical properties, dynamic in vitro degradation and in vivo performance in a rat femoral bone defect model. Porogen addition to CPC showed to decrease compressive strength of all CPC formulations; transition of the crystal phase upon in vitro incubation increased compressive strength. Although dynamic in vitro degradation showed rapid sucrose dissolution within 1 week, no additional effects on CPC degradation or bone formation were observed upon in vivo implantation. © 2019 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1713-1722, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.