Evidence map›Paper›PMID 30920054›Full record

ArticleNMR in biomedicine2019

Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T.

William T Clarke, Mark A Peterzan, Jennifer J Rayner, Rana A Sayeed, Mario Petrou, George Krasopoulos, Hannah A Lake, Betty Raman, William D Watson, Pete Cox and 6 more

Open access · hybridAbstract read
In one paragraph

Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Rapid,Magnetic resonance in medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

William T ClarkeOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0001-7159-7025
Mark A PeterzanOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Jennifer J RaynerOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rana A SayeedDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Mario PetrouDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
George KrasopoulosDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Hannah A LakeDepartment of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
Betty RamanOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
William D WatsonOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Pete CoxDepartment of Physiology Anatomy, University of Oxford, Parks Road, Sherrington Building, Oxford, UK.
Moritz J HundertmarkOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Andrew P AppsOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Craig A LygateDepartment of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
Stefan NeubauerOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Oliver J RiderOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Christopher T RodgersOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine RDM, University of Oxford, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0003-1275-1197
John Radcliffe Hospital · GBCentre for Human Genetics · GBUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

BHF Centre of Research Excellence, OxfordBritish Heart Foundation FS/14/54/30946British Heart Foundation FS/15/80/31803British Heart Foundation RG/13/8/30266Wellcome Trust 098436Wellcome Trust and Royal Society 098436/Z/12/Z
6 · The paper itself

Abstract

Changes in the kinetics of the creatine kinase (CK) shuttle are sensitive markers of cardiac energetics but are typically measured at rest and in the prone position. This study aims to measure CK kinetics during pharmacological stress at 3 T, with measurement in the supine position. A shorter "stressed saturation transfer" (StreST) extension to the triple repetition time saturation transfer (TRiST) method is proposed. We assess scanning in a supine position and validate the MR measurement against biopsy assay of CK activity. We report normal ranges of stress CK forward rate (k

Indexed as

Magnetic Resonance SpectroscopyRestStress, PhysiologicalAdultBiopsyCase-Control StudiesCreatine KinaseFemaleHeartHumansKineticsMaleMiddle AgedMyocardiumObesityPostureCreatine Kinase31P magnetic resonance spectroscopycardiaccreatine kinaseenergy metabolismphosphorussaturation transferStreSTTRiST

Identifiers

PMID30920054
PMCPMC6542687
OpenAlexW2925009583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.